ArticleAntibiotics (Basel, Switzerland)2022
Relationship between Phenotypic and Genotypic Resistance of Subgingival Biofilm Samples in Patients with Periodontitis.
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Review
- A Comprehensive Safety Assessment ofMicroorganisms · 2025Article
- Recent advances in hydrogels for treating periodontal diseases and oral mucosal diseases.Frontiers in bioengineering and biotechnology · 2025Review
- Emergence of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Type IV Pilus-Mediated Inhibition ofMicrobiology spectrum · 2023Article
- Editorial for the Special Issue: "Current Technique for Antibiotic Susceptibility Test: Advantages and Limitations; Need for Next-Generation Test".Antibiotics (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotypic expression of antibiotic resistance genes (ARGs) can hamper the use of antibiotics as adjuncts to subgingival instrumentation in the treatment of periodontitis patients. The aim of the study was to analyze the relationship between the phenotypic and genotypic resistance against ampicillin-sulbactam, clindamycin, doxycycline and metronidazole of subgingival biofilm samples from 19 periodontitis patients. Samples were analyzed with shotgun sequencing and cultivated anaerobically for 7 days on microbiological culture media incorporating antibiotics. All growing isolates were identified to the species level using MALDI-TOF-MS and sequence analysis of the 16S ribosomal RNA (rRNA) gene. Phenotypic resistance was determined using EUCAST-breakpoints. The genetic profile of eight patients matched completely with phenotypical resistance to the tested antibiotics. The positive predictive values varied from 1.00 for clindamycin to 0.57 for doxycycline and 0.25 for ampicillin-sulbactam. No sample contained the
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