Tricyclic Fused Lactams by Mukaiyama Cyclisation of Phthalimides and Evaluation of their Biological Activity.

Lewis T Ibbotson, Kirsten E Christensen, Miroslav Genov, Alexander Pretsch, Dagmar Pretsch, Mark G Moloney

Abstract read

In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lewis T IbbotsonThe Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0003-1078-3371

Kirsten E ChristensenThe Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

Miroslav GenovOxford Antibiotic Group, The Oxford Science Park, Magdalen Centre, Oxford OX4 4GA, UK.ORCID 0000-0001-6854-4387

Alexander PretschOxford Antibiotic Group, The Oxford Science Park, Magdalen Centre, Oxford OX4 4GA, UK.

Dagmar PretschOxford Antibiotic Group, The Oxford Science Park, Magdalen Centre, Oxford OX4 4GA, UK.

Mark G MoloneyThe Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0002-4440-3632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report that phthalimides may be cyclized using a Mukaiyama-type aldol coupling to give variously substituted fused lactam (1,2,3,9b-tetrahydro-5

Indexed as

aldolantibacterialpyrrolidinone

Identifiers

PMID36671210

DOI10.3390/antibiotics12010009

PMCPMC9854654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.