Evidence map›Paper›PMID 36671013›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Quantitative Proteomics Identifies Novel Nrf2-Mediated Adaptative Signaling Pathways in Skeletal Muscle Following Exercise Training.

Anjali Bhat, Rafay Abu, Sankarasubramanian Jagadesan, Neetha Nanoth Vellichirammal, Ved Vasishtha Pendyala, Li Yu, Tara L Rudebush, Chittibabu Guda, Irving H Zucker, Vikas Kumar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  4. CSE/HInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Anjali BhatDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Rafay AbuMass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sankarasubramanian JagadesanDepartment of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Neetha Nanoth VellichirammalDepartment of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Ved Vasishtha PendyalaDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Li YuDepartment of Cellular & Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Tara L RudebushDepartment of Cellular & Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Chittibabu GudaDepartment of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-5393-9316
Irving H ZuckerDepartment of Cellular & Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-3636-7720
Vikas KumarMass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-7513-6832
Lie GaoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-7880-7213
University of Nebraska Medical Center · USGlocal University · IN

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Apar Kishor Ganti · 1985 to 2026
$55.0M
Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLSTEIN, SARAH A · 2016 to 2025
$42.8M
Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2000 to 2021
$37.7M
Skeletal Muscle Nrf2: Exercise-Induced Cardiovascular ProtectionR01HL160820 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GAO, LIE · 2022 to 2025
$2.1M
NCI NIH HHS P30 CA036727NHLBI NIH HHS R01 HL160820NIGMS NIH HHS P20 GM103427NIGMS NIH HHS U54 GM115458NIH HHS 1R01HL160820-01NIMH NIH HHS P30 MH062261
6 · The paper itself

Abstract

Exercise training (ExT) improves skeletal muscle health via multiple adaptative pathways. Nrf2 is a principal antioxidant transcription factor responsible for maintaining intracellular redox homeostasis. In this study, we hypothesized that Nrf2 is essential for adaptative responses to ExT and thus beneficial for muscle. Experiments were carried out on male wild type (WT) and iMS-

Indexed as

exerciseNrf2proteomicsskeletal muscle

Identifiers

PMID36671013
PMCPMC9854705
OpenAlexW4313826098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.