ArticleAnimals : an open access journal from MDPI2023
3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research.
Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
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- A novel 7.5 single-use flexible ureteroscope with in-built temperature and pressure sensors: Is there a limit to reliability and safety? An in vivo experimental study.World journal of urology · 2026Article
- A high-throughput 3D conjunctival spheroid model for standardized in vitro testing.Scientific reports · 2026Article
- Safety Assessment of Enterocin LD3 Purified from a Food-Grade Enterococcus hirae LD3.Probiotics and antimicrobial proteins · 2026Article
- Advancing glioblastoma research by establishing a whole brain slice model.Frontiers in oncology · 2026Article
- Mechanisms of action of the hexane extract ofADMET & DMPK · 2026Article
- Phytochemical Profiling and Neuropharmacological Evaluation of Baccaurea motleyana Bark Extract: In Vivo and In Silico Approaches.TheScientificWorldJournal · 2026Article
- Ultrastructural and Immunohistochemical Study on the Nephrotoxicity Following Intravitreal Administration of the Antifungal Agents Voriconazole and Micafungin in New Zealand White Rabbits.International journal of molecular sciences · 2025Article
- Development and Evaluation of Nystatin-Loaded Novasomal Gel for the Treatment ofGels (Basel, Switzerland) · 2025Article
- A novelParasitology · 2025Article
- Machine Learning Predicts Non-Preferred and Preferred Vertebrate Hosts of Tsetse Flies (Glossina spp.) Based on Skin Volatile Emission Profiles.Journal of chemical ecology · 2025Article
- An In vitro Caco2-Based Model for Measuring Intestinal Bioadhesion Comparable to Ex vivo Models.Small science · 2025Article
- The pig as a medical model for gynecological diseases: an applied perspective.Frontiers in veterinary science · 2025Review
- Clausena harmandiana root extract ameliorates AβBMC complementary medicine and therapies · 2024Article
- Quantitative Synthesis of Microbe-Driven Acclimation and Adaptation in Wild Vertebrates.Evolutionary applications · 2024Review
- Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region.Scientific reports · 2024Article
- Development of ARPE-19-Equipped Ocular Cell Model for In Vitro Investigation on Ophthalmic Formulations.Pharmaceutics · 2023Article
- Progress towards the Replacement of the Rabbit Blood Sugar Test for the Quantitative Determination of the Biological Activity of Insulins (USP <121>) with an In Vitro Assay.Animals : an open access journal from MDPI · 2023Article
- The 3Rs in Experimental Liver Disease.Animals : an open access journal from MDPI · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal experimentation is a vast ecosystem that tries to make different issues such as legislative, ethical and scientific coexist. Research in animal experimentation has made many strides thanks to the 3Rs principle and the attached legislative decrees, but for this very reason, it needs to be evenly implemented both among the countries that have adhered to the decrees and among the team members who design and execute the experimental practice. In this article, we emphasize the importance of the 3Rs principle's application, with a particular focus on the concept of Reduction and related key aspects that can best be handled with the contribution of experts from different fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.