ArticleAnimals : an open access journal from MDPI2023
Etiopathogenesis of Canine Cruciate Ligament Disease: A Scoping Review.
Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Application of Deep Learning-Based Reconstruction to Magnetic Resonance Imaging of Canine Stifle Joint in Healthy Beagles: Achieving Enhanced Image Quality With Reduced Slice Thickness.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- REAC-based bioelectrical neuromodulation as a conservative strategy in canine cranial cruciate ligament rupture: a translational pilot study.BMC veterinary research · 2026Article
- Porous tibial tuberosity advancement without using flange for the treatment of cranial cruciate ligament rupture in dogs-a clinical pilot study.Frontiers in veterinary science · 2026Article
- Combined tibial plateau leveling osteotomy and autologous conditioned serum for functional recovery and delayed osteoarthritis progression in dogs with cranial cruciate ligament rupture.Frontiers in veterinary science · 2026Article
- Three-dimensional analysis of femoral tunnel placement in canine cranial cruciate ligament reconstruction.BMC veterinary research · 2025Article
- Exploring the Potential of Non-Cellular Orthobiologic Products in Regenerative Therapies for Stifle Joint Diseases in Companion Animals.Animals : an open access journal from MDPI · 2025Review
- Article
- Biomechanical Evaluation of a Novel Ceramic Implant for Canine Cranial Cruciate Ligament Rupture Treatment: A Finite Element Analysis Approach.Animals : an open access journal from MDPI · 2024Article
- Osteoarthritis, adipokines and the translational research potential in small animal patients.Frontiers in veterinary science · 2024Review
- The Effect of Therapeutic Exercise on Body Weight Distribution, Balance, and Stifle Function in Dogs following Stifle Injury.Animals : an open access journal from MDPI · 2023Article
- Infrared thermography as a diagnostic tool to detect cranial cruciate ligament deficiency in dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Correlates of estimated lifetime cruciate ligament survival inform potential rupture risk reduction strategies: findings from the Exceptional Aging in Rottweilers Study.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spontaneous rupture of the cranial cruciate ligament in dogs remains a pathoetiologic puzzle. Despite much progress in research over the past years, the systemic and local mechanisms leading to ligament degeneration and structural failure remain largely obscure. This scoping review focuses on pathogenesis and aims at summarizing and interpreting today's knowledge on causes of canine cruciate ligament rupture, i.e., the multifactorial mechanisms leading to degenerative stifle joint disease with collagen matrix degeneration and structural failures. Thus, the initial view of traumatic ligament rupture, fostered by "wear and tear", has clearly been replaced by a new concept of systemic processes linked to progressive degenerative joint disease and ligament failure; thus, the term "cranial cruciate ligament disease" has been coined and is generally accepted. In addition, cruciate ligament rupture in people shares some similarities with the lesion in dogs; therefore, the review also includes comparative studies. The methods used were based on the PRISMA-ScR model (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.