ArticleChildren (Basel, Switzerland)2023
Impact of Delayed Time to Antibiotics in Medical and Surgical Necrotizing Enterocolitis.
Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- A standardized universal protocol for using adjunct abdominal ultrasound at the time of diagnosis for suspected necrotizing enterocolitis.Pediatric radiology · 2025Article
- A Nomogram for Predicting Surgical Risk in Neonates with Necrotizing Enterocolitis: A Retrospective Cohort Study.Indian journal of pediatrics · 2025Article
- Present and future of microbiome-targeting therapeutics.The Journal of clinical investigation · 2025Review
- Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Risk of neurodevelopmental impairment in Swedish preterm children treated for necrotizing enterocolitis: retrospective cohort study.BJS open · 2024Article
- Practical Issues in the Treatment of Preterm Infants.Children (Basel, Switzerland) · 2023Article
- Exploring the links between necrotizing enterocolitis and cow's milk protein allergy in preterm infants: a narrative review.Frontiers in pediatrics · 2023Review
- Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
This study investigated whether delayed receipt of antibiotics in infants with necrotizing enterocolitis (NEC) is associated with disease severity. In this retrospective, single-center cohort study of infants diagnosed with NEC over 4 years, we compared the timing of antibiotic administration in infants (time order placed to time of receipt) in medical and surgical NEC. Cases were independently reviewed, then various clinical factors were compared. Of 46 suspected cases, 25 were confirmed by a panel of radiologists with good interrater reliability (ICC 0.657; p < 0.001). Delays in antibiotic receipt were 1.7× greater in surgical than medical NEC cases (p = 0.049). Every hour after order entry increased the adjusted odds of surgical NEC by 2.4 (1.08−5.23; p = 0.032). Delayed antibiotic receipt was more common in infants with surgical than medical NEC. Larger studies will be needed to investigate if optimizing antibiotic expediency could improve intestinal outcomes.
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Registered trials
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