Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 4 institutions in 2 countries.
Martin FärdigDepartment of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0003-2274-752X
Hrefna Katrín GudmundsdóttirDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, 0424 Oslo, Norway.ORCID 0000-0002-1248-2874
Angela HoyerDepartment of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.
Karen Eline Stensby BainsDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, 0424 Oslo, Norway.
Catarina AlmqvistAstrid Lindgren Children's Hospital, Karolinska University Hospital, 171 64 Stockholm, Sweden.
Christine Monceyron JonassenDepartment of Virology, Norwegian Institute of Public Health, 0213 Oslo, Norway.
Eva Maria RehbinderDepartment of Dermatology and Vaenerology, Oslo University Hospital, 0424 Oslo, Norway.
Håvard O SkjervenDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, 0424 Oslo, Norway.
Anne Cathrine StaffInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.
Riyas VettukattilDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, 0424 Oslo, Norway.ORCID 0000-0002-2152-4933
Cilla SöderhällDepartment of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-8397-3080
Karin C Lødrup CarlsenDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, 0424 Oslo, Norway.
Björn NordlundDepartment of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.
Oslo University Hospital · NOKarolinska University Hospital · SEKarolinska Institutet · SENorwegian Institute of Public Health · NO
Funding
Arne Ingel's Legat NAAstma- och Allergiförbundet K62214053Barnestiftelsen at Oslo University Hospital NAForskningsrådet om Hälsa, Arbetsliv och Välfärd K62202103Fürst Medical Laboratory, Oslo, Norway NAHealth and Rehabilitation Norway 36730; 36774Hjärt-Lungfonden K62214063Insamlingsstiftelsen Cancer- och Allergifonden NAKarolinska Institutet K62221012KI grants NAKonsul Th C Berghs Stiftelse K62214073Norges Astma- og Allergiforbund NANorges Forskningsråd 240216Norges Miljø- og Biovitenskapelige Universitet NANorwegian Society of Dermatology and Venerology NAOslo University Hospital NARegion Stockholm (ALF-project and individual grants) NARoche NASFO-V, Karolinska Institutet, Sweden K62221012Stiftelsen Jubileumsklinikens Forskningsfond mot Cancer NAStiftelsen Sven Jerrings Fond NASvenska Läkaresällskapet NASwedish Order of Freemasons Foundation Barnhuset K62222023Sykehuset Østfold NAThe Frithjof Nansen Institute NAThe Hesselman Foundation NAThe Kloster Foundation NAThe Magnus Bergwall Foundation NAThe Pediatric Research Foundation at Astrid Lindgren Children's Hospital NAThe Regional Health Board South East 2013118; 2015047; 2016093; 2017008; 2017023; 2022097Thermo Fisher Scientific NAThe Samaritan Foundation for Pediatric research NAThe Swedish Heart-Lung Foundation, Sweden K62214063University of Oslo NAVårdalstiftelsen K62202053Vetenskapsrådet K62202063
6 · The paper itself
Abstract
Background: The relationship between the skin barrier- and lung function in infancy is largely unexplored. We aimed to explore if reduced skin barrier function by high transepidermal water loss (TEWL), or manifestations of eczema or Filaggrin (FLG) mutations, were associated with lower lung function in three-month-old infants. Methods: From the population-based PreventADALL cohort, 899 infants with lung function measurements and information on either TEWL, eczema at three months of age and/or FLG mutations were included. Lower lung function by tidal flow-volume loops was defined as a ratio of time to peak tidal expiratory flow to expiratory time (tPTEF/tE) <0.25 and a tPTEF <0.17 s (<25th percentile). A high TEWL >8.83 g/m2/h (>75th percentile) denoted reduced skin barrier function, and DNA was genotyped for FLG mutations (R501X, 2282del4 and R2447X). Results: Neither a high TEWL, nor eczema or FLG mutations, were associated with a lower tPTEF/tE. While a high TEWL was associated with a lower tPTEF; adjusted OR (95% CI) 1.61 (1.08, 2.42), the presence of eczema or FLG mutations were not. Conclusions: Overall, a high TEWL, eczema or FLG mutations were not associated with lower lung function in healthy three-month-old infants. However, an inverse association between high TEWL and tPTEF was observed, indicating a possible link between the skin barrier- and lung function in early infancy.
Indexed as
eczemafilaggrininfantPreventADALLrespiratory function teststransepidermal water loss
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Skin Barrier Function and Infant Tidal Flow-Volume Loops-A Population-Based Observational Study. · full record | OpenQuestion