Evidence map›Paper›PMID 36670473›Full record

ArticleJournal of experimental & clinical cancer research : CR2023

Long-term exposure to house dust mites accelerates lung cancer development in mice.

Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Griffin, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M González-Navajas and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. CSF2 polarized neutrophils and invaded renal cancer cellsOpen medicine (Warsaw, Poland) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 4 countries.

Dongjie WangDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Wen LiDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Natalie AlbashaDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Lindsey GriffinDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Han ChangDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Lauren AmayaDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Sneha GangulyDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Liping ZengDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Bora KeumDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
José M González-NavajasNetworked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Hospital General Universitario de Alicante, Alicante, Spain.
Matt LevinCell IDx Inc, San Diego, CA, USA.
Zohreh AkhavanAghdamCell IDx Inc, San Diego, CA, USA.
Helen SnyderCell IDx Inc, San Diego, CA, USA.
David SchwartzCell IDx Inc, San Diego, CA, USA.
Ailin TaoThe State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Center for Immunology, Inflammation and Immune-Mediated Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Laela M BoosherhriDivision of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego, La Jolla, CA, USA.
Hal M HoffmanDivision of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego, La Jolla, CA, USA.
Michael RoseTissue Technology Shared Resource, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Monica Valeria EstradaTissue Technology Shared Resource, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Nissi VarkiDepartment of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Scott HerdmanDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Maripat CorrDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.
Nicholas J G WebsterDivision of Endocrinology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Eyal RazDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA. eraz@ucsd.edu.
Samuel BertinDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA. sbertin@ucsd.edu.ORCID http://orcid.org/0000-0003-2340-959X
University of California San Diego · USCell IDx (United States) · USCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESChinese Academy of Medical Sciences & Peking Union Medical College · CNKorea University · KRSecond Affiliated Hospital of Guangzhou Medical University · CN

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DCR01HL141999 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAZ, EYAL, WEBSTER, NICHOLAS J · 2019 to 2022
$2.9M
Control of mucosal immunity by Gas- vs Gai-linked GPCR signaling in dendritic cellsU01AI125860 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAZ, EYAL · 2016 to 2020
$2.3M
BLR&D Research Career Scientist Award ApplicationIK6BX005224 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WEBSTER, NICHOLAS J · 2020 to 2025
–
BLRD VA IK6 BX005224NCI NIH HHS P30 CA023100NHLBI NIH HHS R01 HL141999NIAID NIH HHS U01 AI125860NIDDK NIH HHS P30 DK063491NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

backgroundIndividuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic exposure to house dust mites (HDM), a common indoor aeroallergen associated with the development of asthma, accelerates LC development through the induction of chronic lung inflammation (CLI). 

methodsThe effects of HDM and heat-inactivated HDM (HI-HDM) extracts were evaluated in two preclinical mouse models of LC (a chemically-induced model using the carcinogen urethane and a genetically-driven model with oncogenic Kras

conclusionsCollectively, these data indicate that long-term exposure to HDM can accelerate lung tumorigenesis in susceptible hosts (e.g., mice and potentially humans exposed to lung carcinogens or genetically predisposed to develop LC).

Indexed as

AsthmaLung NeoplasmsAnimalsDisease Models, AnimalHumansLungMiceNLR Family, Pyrin Domain-Containing 3 ProteinPyroglyphidaeTumor MicroenvironmentNLR Family, Pyrin Domain-Containing 3 ProteinCCL2Chronic inflammationHouse dust mitesIL-1βKrasLung cancerMacrophagesNLRP3Tumor microenvironmentUrethane

Identifiers

PMID36670473
PMCPMC9863279
OpenAlexW4317582093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.