Evidence map›Paper›PMID 36670465›Full record

ArticleMolecular brain2023

Modulating and monitoring the functionality of corticostriatal circuits using an electrostimulable microfluidic device.

Sukmin Han, Seokyoung Bang, Hong Nam Kim, Nakwon Choi, Sung Hyun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sukmin HanDepartment of Neuroscience, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.
Seokyoung BangBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Hong Nam KimBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Nakwon ChoiBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Sung Hyun KimDepartment of Neuroscience, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. sunghyunkim@khu.ac.kr.ORCID 0000-0002-3166-9941
Korea Institute of Brain Science · KRKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central nervous system is organized into different neural circuits, each with particular functions and properties. Studying neural circuits is essential to understanding brain function and neuronal diseases. Microfluidic systems are widely used for reconstructing and studying neural circuits but still need improvement to allow modulation and monitoring of the physiological properties of circuits. In this study, we constructed an improved microfluidic device that supports the electrical modulation of neural circuits and proper reassembly. We demonstrated that our microfluidic device provides a platform for electrically modulating and monitoring the physiological function of neural circuits with genetic indicators for synaptic functionality in corticostriatal (CStr) circuits. In particular, our microfluidic device measures activity-driven Ca

Indexed as

NeuronsSynaptic TransmissionLab-On-A-Chip DevicesAction potentialCa2+ dynamicsCorticostriatal (CStr) circuitMicrofluidic deviceSynapseSynaptic transmission

Identifiers

PMID36670465
PMCPMC9863144
OpenAlexW4317600119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.