Evidence map›Paper›PMID 36670149›Full record

ArticleScientific reports2023

Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder.

Vardan Arutiunian, Militina Gomozova, Alina Minnigulova, Elizaveta Davydova, Darya Pereverzeva, Alexander Sorokin, Svetlana Tyushkevich, Uliana Mamokhina, Kamilla Danilina, Olga Dragoy

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vardan ArutiunianCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, 1920 Terry Ave., Seattle, WA, 98101, USA. vardan.arutyunyan89@gmail.com.
Militina GomozovaCenter for Language and Brain, HSE University, Moscow, Russia.
Alina MinnigulovaCenter for Language and Brain, HSE University, Moscow, Russia.
Elizaveta DavydovaFederal Resource Center for ASD, Moscow State University of Psychology and Education, Moscow, Russia.
Darya PereverzevaFederal Resource Center for ASD, Moscow State University of Psychology and Education, Moscow, Russia.
Alexander SorokinFederal Resource Center for ASD, Moscow State University of Psychology and Education, Moscow, Russia.
Svetlana TyushkevichFederal Resource Center for ASD, Moscow State University of Psychology and Education, Moscow, Russia.
Uliana MamokhinaFederal Resource Center for ASD, Moscow State University of Psychology and Education, Moscow, Russia.
Kamilla DanilinaFederal Resource Center for ASD, Moscow State University of Psychology and Education, Moscow, Russia.
Olga DragoyCenter for Language and Brain, HSE University, Moscow, Russia.
Moscow State University of Psychology & Education · RUNational Research University Higher School of Economics · RUHaskins Laboratories · USSeattle Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD) but its neural basis is poorly understood. Using structural magnetic resonance imaging (MRI), the present study provides the whole-brain comparison of both volume- and surface-based characteristics between groups of children with and without ASD and investigates the relationships between these characteristics in language-related areas and the language abilities of children with ASD measured with standardized tools. A total of 36 school-aged children participated in the study: 18 children with ASD and 18 age- and sex-matched typically developing controls. The results revealed that multiple regions differed between groups of children in gray matter volume, gray matter thickness, gyrification, and cortical complexity (fractal dimension). White matter volume and sulcus depth did not differ between groups of children in any region. Importantly, gray matter thickness and gyrification of language-related areas were related to language functioning in children with ASD. Thus, the results of the present study shed some light on the structural brain abnormalities associated with language impairment in ASD.

Indexed as

Autism Spectrum DisorderLanguage Development DisordersBrainCerebral CortexChildHumansMagnetic Resonance Imaging

Identifiers

PMID36670149
PMCPMC9860052
OpenAlexW4317612180

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.