ArticleNPJ Parkinson's disease2023
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies.
Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention.The journal of prevention of Alzheimer's disease · 2025Trial
- Decoding Prodromal Lewy Body Disease: Clinical Differences Between Isolated REM Sleep Behavior Disorder and Hyposmia With Dopamine Transporter Deficit.European journal of neurology · 2026Article
- The role of quantitative susceptibility mapping in dementia with Lewy Bodies.NeuroImage. Clinical · 2026Article
- Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes?Frontiers in neuroscience · 2026Article
- Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70 years old.BMC medicine · 2025Article
- Regional brain aging patterns reveal disease-specific pathways of neurodegeneration.medRxiv : the preprint server for health sciences · 2025Article
- Separating dementia with Lewy bodies from Alzheimer's disease dementia using a volumetric MRI classifier.European radiology · 2025Article
- MRI-specific signature of dementia with Lewy bodies-a step towards improved differential diagnosis of the dementia spectrum.European radiology · 2025Article
- Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies.Psychological medicine · 2025Article
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum.Brain communications · 2025Article
- MRI subtypes in Parkinson's disease across diverse populations and clustering approaches.NPJ Parkinson's disease · 2024Article
- High pulse wave velocity is associated with enlarged perivascular spaces in dementia with Lewy bodies.Scientific reports · 2024Article
- Sex differences in brain atrophy in dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebrovascular and Alzheimer's disease biomarkers in dementia with Lewy bodies and other dementias.Brain communications · 2024Article
- Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?Alzheimer's research & therapy · 2023Article
- Occipital atrophy signature in prodromal Lewy bodies disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- The utility of a composite endpoint for tracking disease progression in Lewy body dementia.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
26 authors at 11 institutions in 8 countries.
Funding
Abstract
Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.