Evidence map›Paper›PMID 36670054›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2023

Why Therapeutic Trials Fail in Primary Tauopathies.

Nahid Olfati, Hamidreza Ghodsi, Ece Bayram, Irene Litvan

Abstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. AAV delivery of artificial miRNA targeting MAPT for the reduction of tau pathology in Alzheimer's disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nahid OlfatiParkinson and Other Movement Disorders Center, Department of Neurosciences, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-4621-2490
Hamidreza GhodsiParkinson and Other Movement Disorders Center, Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
Ece BayramParkinson and Other Movement Disorders Center, Department of Neurosciences, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-6875-4242
Irene LitvanParkinson and Other Movement Disorders Center, Department of Neurosciences, University of California San Diego, La Jolla, California, USA.

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI John Kornak · 2019 to 2026
$120.9M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Dementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6M
Clinical Coordination Center for STEADY-PD3U01NS080818 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIMUNI, TANYA · 2014 to 2018
$13.0M
Genetic and Environmental Risk Factors for PSPR01AG024040 · NIA · UNIVERSITY OF LOUISVILLE · PI LITVAN, IRENE · 2006 to 2010
$2.7M
Training in Research to Assure Neuroscience Scholars Cultivate Expertise in Notable Disparities Science (TRANSCENDS)R25NS098999 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BRUCE OVBIAGELE · 2017 to 2026
$2.5M
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasR00AG073453 · NIA · UNIVERSITY OF COLORADO DENVER · PI ECE BAYRAM · 2024 to 2026
$725k
Real-Time L-Dopa Monitoring for Improved Management of Parkinson DiseaseR21NS114764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITVAN, IRENE, WANG, JOSEPH · 2020 to 2020
$434k
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasK99AG073453 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAYRAM, ECE · 2022 to 2023
$251k
NIA NIH HHS K99 AG073453NIA NIH HHS P01 AG019724NIA NIH HHS R00 AG073453NIA NIH HHS R01 AG024040NIA NIH HHS R01 AG038791NIA NIH HHS U19 AG063911NINDS NIH HHS R21 NS114764NINDS NIH HHS R25 NS098999NINDS NIH HHS U01 NS080818NINDS NIH HHS U01 NS100610
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

TauopathiesHumanstau Proteinstau Proteins

Identifiers

PMID36670054
PMCPMC10398638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.