Evidence map›Paper›PMID 36669949›Full record

ReviewTrends in genetics : TIG2023

Polygenic sex determination in vertebrates - is there any such thing?

Manfred Schartl, Arthur Georges, Jennifer A Marshall Graves

Open access · greenAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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  12. Turnover of multiple sex chromosomes inFrontiers in genetics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Manfred SchartlThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA; Developmental Biochemistry, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: phch1@biozentrum.uni-wuerzburg.de.
Arthur GeorgesInstitute for Applied Ecology, University of Canberra, ACT, 2601, Australia.
Jennifer A Marshall GravesDepartment of Environment and Genetics, La Trobe University, Melbourne, Victoria 3068, Australia.
La Trobe University · AUTexas State University · USUniversity of Canberra · AU

Funding

Advancement of the Xiphophorus Model for Studying DiseaseR24OD031467 · OD · TEXAS STATE UNIVERSITY · PI Yuan Lu, Manfred Schartl · 2022 to 2026
$3.8M
Development of genome-modified XiphophorusR21OD031910 · OD · TEXAS STATE UNIVERSITY · PI SCHARTL, MANFRED · 2022 to 2023
$412k
NIH HHS R21 OD031910NIH HHS R24 OD031467
6 · The paper itself

Abstract

Genetic sex determination (SD) in most vertebrates is controlled by a single master sex gene, which ensures a 1:1 sex ratio. However, more complex systems abound, and several have been ascribed to polygenic SD (PSD), in which many genes at different loci interact to produce the sexual phenotype. Here we examine claims for PSD in vertebrates, finding that most constitute transient states during sex chromosome turnover, or aberrant systems in species hybrids. To avoid confusion about terminology, we propose a consistent nomenclature for genetic SD systems.

Indexed as

Sex Determination ProcessesVertebratesAnimalsMultifactorial InheritancePhenotypeSex Chromosomesgenetic sex determinationpolygenicquantitative trait locisex chromosomeSRYtemperature-dependent sex determination

Identifiers

PMID36669949
PMCPMC10148267
OpenAlexW4317376566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.