ReviewMayo Clinic proceedings2023
The Digitization and Decentralization of Clinical Trials.
Review in Mayo Clinic proceedings, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Recruiting and Consenting Decentralized Clinical Trial Participants-Learnings from the Trials@Home RADIAL Proof-of-Concept Trial.Clinical pharmacology and therapeutics · 2025Trial
- Current Landscape of Investigator-Initiated Decentralized Clinical Trials in Japan: A Nationwide Survey.Therapeutic innovation & regulatory science · 2026Article
- Addressing the Key Challenges of Decentralized Clinical Trials in Europe: Multistakeholder Perspective Delphi Study.Journal of medical Internet research · 2026Article
- SWOT analysis of decentralised clinical trials from an ethical, legal, regulatory and operational perspective.BMC medical ethics · 2026Article
- Decentralized clinical trials: A comprehensive analysis of trends, technologies, and global challenges.PLOS digital health · 2026Article
- Data capture, collection, management, and storage systems for clinical research: A scoping review protocol.PloS one · 2026Article
- A Community-Engaged Approach for Assessment of Cortisol Dynamic Range and Multilevel Chronic Stress in African Americans: FAITH! Heart Health+ Ancillary Study.Journal of participatory medicine · 2025Article
- Decentralized Clinical Trials: Governance, Ethics and Medico-Legal Issues for the New Paradigm of Research with a Focus on Cardiovascular Field.Medical sciences (Basel, Switzerland) · 2025Review
- Collecting at-Home Biometric Measures for Longitudinal Research From the i3C: Feasibility and Acceptability Study.JMIR human factors · 2025Article
- Advancements in Electronic Medical Records for Clinical Trials: Enhancing Data Management and Research Efficiency.Cancers · 2025Review
- A Pilot Study of the Home-Based 12-Lead Electrocardiogram in Clinical Practice.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Decentralized Clinical Trials in the Era of Real-World Evidence: A Statistical Perspective.Clinical and translational science · 2025Review
- Urban-Suburban Differences in Public Perspectives on Digitalizing Pediatric Research: Cross-Sectional Survey Study.Journal of medical Internet research · 2025Article
- Connecting research and community: a methodological framework for investigating CMV transmission in childcare settings.Frontiers in pediatrics · 2025Article
- Consortium-driven rapid software validation for Research Electronic Data Capture (REDCap).Journal of clinical and translational science · 2025Article
- Community-based participatory design of a decade: the FAITH! Cardiovascular Health and Wellness Program.Frontiers in public health · 2025Article
- Study on knowledge, practices, and attitudes toward decentralized clinical trials among the clinical trial practitioners in China.Frontiers in medicine · 2025Article
- Assessing Artificial Intelligence Solution Effectiveness: The Role of Pragmatic Trials.Mayo Clinic proceedings. Digital health · 2024Review
- The Introduction of AI Into Decentralized Clinical Trials: Preparing for a Paradigm Shift.JACC. Advances · 2024Article
- Digital Solutions Observed in Clinical Trials: A Formative Feasibility Scoping Review.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Now, more than ever, digital technology has made its way into the daily lives of billions across the globe, and the widespread use of this technology has also allowed a digital window into consumers' and patients' daily lives, respectively. In a similar way, the practice of medicine has digitally evolved with the application of electronic health records and development of wearable/portable consumer-based medical devices (eg, Apple Watch ECG and Kardia Mobile by AliveCor). Alongside the increased use of digital technology in clinical care (eg, telehealth and wearable arrhythmia detection), clinical investigators have harnessed this powerful stockpile of data to gain insight into what happens to patients beyond the clinic walls. In this thematic review, we show the impact of digital advancements on the clinical trial process from recruitment and enrollment to interventions and data collection. We also show the pragmatism of this decentralized process and how it will mitigate the limitations of conventional randomized controlled trials. Finally, while pushing the boundaries of tech, we also describe a few limitations of this rapidly growing field to understand better what gaps need to be bridged in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.