Evidence map›Paper›PMID 36669881›Full record

ArticleTobacco control2024

Reducing attractiveness of e-liquids: proposal for a restrictive list of tobacco-related flavourings.

Jeroen L A Pennings, Anne Havermans, Erna J Z Krüsemann, Dion Zijtveld, Eva H W Huiberts, Peter M J Bos, Erna Schenk, Wouter F Visser, Ingrid M E Bakker-'t Hart, Yvonne C M Staal and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Tobacco control, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Mapping the flavoring landscape: a comparative analysis of tobacco and related products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  3. Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jeroen L A PenningsCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands jeroen.pennings@rivm.nl.ORCID 0000-0002-9188-6358
Anne HavermansCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.ORCID 0000-0003-2874-6560
Erna J Z KrüsemannCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Dion ZijtveldCentre for Safety of Substances and Products, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Eva H W HuibertsCentre for Safety of Substances and Products, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Peter M J BosCentre for Safety of Substances and Products, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Erna SchenkCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Wouter F VisserCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.ORCID 0000-0003-1129-262X
Ingrid M E Bakker-'t HartCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.ORCID 0000-0001-6632-783X
Yvonne C M StaalCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.ORCID 0000-0002-7187-0121
Reinskje TalhoutCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveElectronic cigarettes are addictive and harmful, and flavour is a key factor determining their abuse liability. Both adult smokers and young non-smokers like sweet and fruity flavours in particular. In order to discourage e-cigarette use among youth, the Dutch government announced in 2020 to only allow tobacco flavours in e-liquids. We propose a restrictive list of flavourings that will only enable the production of e-liquids with a tobacco flavour.

methodsWe used e-liquid ingredient data notified via the European Common Entry Gate system before the government's announcement. First, we classified all e-liquids into flavour categories, and continued with the set of flavourings present in tobacco e-liquids. Five selection criteria related to prevalence of use, chemical composition, flavour description and health effects were defined to compile a restrictive list of tobacco flavourings.

resultsE-liquids marketed as having tobacco flavour contained 503 different flavourings, some with tobacco flavour, but also other (such as sweet) flavours. We excluded (1) 330 flavourings used in <0.5% of e-liquids, (2) 77 used less frequently in tobacco than in all e-liquids, (3) 13 plant extracts, (4) 60 that are sweet or not associated with a tobacco flavour and (5) 7 flavourings with hazardous properties. This resulted in a final list of 16 flavourings.

conclusionsImplementing this restrictive list will likely discourage e-cigarette use among youth, but could also make e-cigarettes less attractive as smoking cessation aid.

Indexed as

Electronic Nicotine Delivery SystemsSmoking CessationTobacco ProductsVapingFlavoring AgentsHumansSmokersFlavoring AgentsElectronic nicotine delivery devicesPublic policyToxicology

Identifiers

PMID36669881
PMCPMC10958261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.