ArticleGenome biology and evolution2023
Genome-Scale Analysis Reveals Extensive Diversification of Voltage-Gated K+ Channels in Stem Cnidarians.
Article in Genome biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis.Nature communications · 2026Article
- Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution.Nature communications · 2025Article
- Neurite branching is associated with mixed microtubule polarity in sea anemone neurons.The Journal of experimental biology · 2025Article
- Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels.bioRxiv : the preprint server for biology · 2025Article
- Decoding the Functional Interactome of Non-Model Organisms with PHILHARMONIC.bioRxiv : the preprint server for biology · 2025Article
- Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels.The Journal of general physiology · 2025Article
- Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology.Toxins · 2024Article
- Molecular Insights into the Low Complexity Secreted Venom of Calliactis polypus.Genome biology and evolution · 2024Article
- A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated KProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functional analysis of ctenophore Shaker KBiophysical journal · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ion channels are highly diverse in the cnidarian model organism Nematostella vectensis (Anthozoa), but little is known about the evolutionary origins of this channel diversity and its conservation across Cnidaria. Here, we examined the evolution of voltage-gated K+ channels in Cnidaria by comparing genomes and transcriptomes of diverse cnidarian species from Anthozoa and Medusozoa. We found an average of over 40 voltage-gated K+ channel genes per species, and a phylogenetic reconstruction of the Kv, KCNQ, and Ether-a-go-go (EAG) gene families identified 28 voltage-gated K+ channels present in the last common ancestor of Anthozoa and Medusozoa (23 Kv, 1 KCNQ, and 4 EAG). Thus, much of the diversification of these channels took place in the stem cnidarian lineage prior to the emergence of modern cnidarian classes. In contrast, the stem bilaterian lineage, from which humans evolved, contained no more than nine voltage-gated K+ channels. These results hint at a complexity to electrical signaling in all cnidarians that contrasts with the perceived anatomical simplicity of their neuromuscular systems. These data provide a foundation from which the function of these cnidarian channels can be investigated, which will undoubtedly provide important insights into cnidarian physiology.
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