SynthesisThe Lancet. Global health2023
A global core outcome measurement set for snakebite clinical trials.
Synthesis in The Lancet. Global health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Core outcome set for intervention research on snakebite envenomation in South Asia.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2026Pooled it
- Snakebite-Associated Infections: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2024Pooled it
- Trial
- Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial.BMJ global health · 2024Trial
- Venom variation and the future of antivenom design: Integrating population venomics, evolutionary toxinology, and precision therapeutics.Toxicon: X · 2026Review
- Large animal models for the assessment of snakebite envenoming therapies.npj drug discovery · 2026Review
- Analysis of factors influencing skin sensitivity test results of antivenom and its potential correlation with allergic reactions: a retrospective cohort study.Frontiers in allergy · 2026Article
- Long-Term Clinical Outcomes of Rattlesnake Envenomation in Arizona Following Treatment With Crofab vs Anavip: A Retrospective Observational Study.Journal of the American College of Emergency Physicians open · 2025Article
- Symptoms and Management of Painful Progressive Swelling in Eswatini Snakebite Patients: A Prospective Observational Study.The American journal of tropical medicine and hygiene · 2025Observational
- Global emergency medicine: A scoping review of the literature from 2023.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Article
- Handheld Point-of-Care Devices for Snakebite Coagulopathy: A Scoping Review.Thrombosis and haemostasis · 2025Article
- The epidemiology of snakebites, treatment-seeking behaviour, and snakebite management in the department of Ogooué et des Lacs, Gabon, Central Africa: a cross-sectional community and health facility-based survey.Journal of global health · 2025Article
- Bite First, Bleed Later: How PhilippineToxins · 2025Article
- Article
- Article
- Functional Disability at 3 Months in Patients with Residual Limb Swelling after Snakebite Envenoming.The American journal of tropical medicine and hygiene · 2024Article
- Landscape of toxin-neutralizing therapeutics for snakebite envenoming (2015-2022): Setting the stage for an R&D agenda.PLoS neglected tropical diseases · 2024Article
- ImprovingF1000Research · 2024Article
- Mobile Critical Care in Resource-Limited Settings: An Unmet Need.Annals of global health · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Funding
Abstract
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials-mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.