ArticleThe Journal of clinical endocrinology and metabolism2023
Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03290235 (The Extension Study of Phase IV Clinical Trial of Pegylated Somatropin), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Extension Study of Phase IV Clinical Trial of Pegylated Somatropin (PEG Somatropin) to Treat Growth Retardation Caused by Endogenous Growth Hormone Deficiency in Children
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Weekly long-acting growth hormone versus daily growth hormone therapy on quality of life, efficacy, and safety in children with short stature: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Comparison between long-acting pegylated and daily recombinant human growth hormone for pediatric growth hormone deficiency a systematic review.Scientific reports · 2025Pooled it
- A Phase 2 Study of PEGylated Recombinant Human Growth Hormone for 52 Weeks in Short Children Born Small for Gestational Age in China.Clinical endocrinology · 2025Trial
- Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone.MedComm · 2026Article
- Analysis of differences in response to long-acting growth hormone therapy and influencing factors between patients with idiopathic short stature (ISS) and growth hormone deficiency (GHD).Translational pediatrics · 2026Article
- Metabolic and bone effects of long-acting polyethylene glycol-recombinant human growth hormone in growth hormone deficiency during the transition period: a prospective study.Annals of pediatric endocrinology & metabolism · 2026Article
- PEG-rhGH successfully improved the height of a patient with rare 45,X[40]/46,XY[31] disorder of sex development: the first reported case.Translational pediatrics · 2026Article
- Optimization of dosing regimens for the long-acting growth hormone pegpesen: A population PK/PD modeling approach.Journal of endocrinological investigation · 2026Article
- Case Report: Possible improvement of near-adult height with PEG-rhGH and letrozole in a late-puberty boy with atypical Noonan syndrome and bone age/height age discrepancy: a novel therapy.Frontiers in pediatrics · 2026Article
- Efficacy and Safety of PEGylated Recombinant Human Growth Hormone in Children With Growth Hormone Deficiency and Idiopathic Short Stature: A Real-World Cohort Study.International journal of endocrinology · 2026Article
- 8-Year Safety and Efficacy of Long-Acting GH Therapy in Pediatric IGHD II with Chiari Malformation Type 1: A Case Report with Review of Literature.Pediatric health, medicine and therapeutics · 2026Article
- Comparative Efficacy and Safety of Once-Weekly Pegylated Recombinant Human Growth Hormone Versus Daily Growth Hormone Therapy in Children: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- History and Current Status of Growth Hormone Treatment in Children.Paediatric drugs · 2025Article
- Real-Life Growth Hormone Treatment Patterns in Children from China: A Report from Two Databases.Advances in therapy · 2025Observational
- Five-year safety and growth response of long-acting PEGylated recombinant human growth hormone in children with growth hormone deficiency-data from CGLS database.European journal of pediatrics · 2025Observational
- Long-Term Efficacy and Safety of Growth Hormone in Children Suffering from Short Stature in China (CGLS): An Open-Label, Multicenter, Prospective and Retrospective, Observational Study.Advances in therapy · 2025Observational
- Extending curve matching with flexible hyperparameter selection to predict response to long-acting PEGylated growth hormone treatment in growth hormone deficiency children: method development and validation.Journal of endocrinological investigation · 2025Article
- The Associations Between Depression, Subjective Sleep Quality, and Health-Related Quality of Life in Patients with Meige Syndrome: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- Factors affecting growth hormone treatment in short stature children born small for gestational age in China: a single-centre, real-world study.Endocrine · 2024Article
- Effect of long-acting PEGylated growth hormone for catch-up growth in children with idiopathic short stature: a 2-year real-world retrospective cohort study.European journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
82 authors at 20 institutions in 1 country.
Ling HouDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ke HuangDepartment of Endocrinology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.ORCID 0000-0002-1605-4615
Chunxiu GongDepartment of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing 100045, China.
Feihong LuoDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
Haiyan WeiDepartment of Endocrinology and Metabolism, Genetics, Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University), Zhengzhou 450018, China.
Liyang LiangDepartment of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Hongwei DuDepartment of Paediatrics, First Hospital of Jilin University, Changchun 130021, China.
Jianping ZhangDepartment of Pediatrics, Ningbo Women & Children's Hospital, Ningbo 315012, China.
Yan ZhongDepartment of Child Health Care, Hunan Children's Hospital, Changsha 410007, China.
Ruimin ChenDepartment of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350005, China.
Xinran ChenDepartment of Pediatric Endocrine Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, Chengdu 610074, China.
Jiayan PanDepartment of Pediatrics, Wuhu First People's Hospital, Wuhu 241000, China.
Xianjiang JinDepartment of Genetics and Endocrinology, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Ting ZengDepartment of Child Health Care, Liuzhou Maternilty and Child Heulthcare Hospital, Liuzhou, Guangxi 545001, China.
Wei LiaoDepartment of Pediatrics, First Affiliated Hospital of Army Medical University (Thrid Military Medical University), Chongqing 400038, China.
Deyun LiuDepartment of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
Dan LanDepartment of Pediatrics, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Shunye ZhuDepartment of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Zhiya DongDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai 200025, China.
Huamei MaDepartment of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Yu YangDepartment of Endocrinology and Genetics, Jiangxi Provincial Children's Hospital, Affiliated Children's Hospital of Nanchang University, Nanchang 330006, China.
Feng XiongDepartment of Endocrinology, Children's Hospital of Chongqing Medical University, Chongqing 400016, China.
Ping LuDepartment of Pediatrics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Shengquan ChengDepartment of Pediatrics, First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.
Xuefan GuDepartment of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Runming JinDepartment of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yu LiuDepartment of Endocrine and Genetic Metabolism, Maternal and Child Health-Care Hospital in Guiyang, Guiyang 550003, China.
Jinzhun WuDepartment of Pediatrics, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Xu XuDepartment of Endocrinology, Wuxi Children's Hospital, Wuxi 214023, China.
Linqi ChenDepatment of Endocrinology, Children's Hospital of Soochow University, Suzhou 215025, China.
Qin DongDepartment of Pediatrics, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310000, China.
Hui PanKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
Zhe SuDepartment of Endocrinology, Shenzhen Children's Hospital, Shenzhen 518038, China.
Lijun LiuDepartment of Endocrinology, Genetics and Metabolism, Hebei Children's Hospital, Shijiazhuang 050031, China.
Xiaoming LuoDepartment of Pediatrics, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
Shining NiDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Zhihong ChenDepartment of Pediatric Endocrinology, Metabolism & Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Yuhua HuDepartment of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Chunlin WangDepartment of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Jing LiuDepartment of Pediatrics, Changchun Children's Hospital, Changchun, Jilin 130000, China.
Li LiuDepartment of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
Biao LuDepartment of Pediatrics, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Xinli WangDepartment of Pediatric, Peking University Third Hospital, Beijing 100191, China.
Yunfeng WangDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China.
Fan YangDepartment of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Manyan ZhangDepartment of Pediatrics, Shaoxing Second Hospital, Shaoxing 312000, China.
Lizhi CaoDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
GeLi LiuDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin 300052, China.
Hui YaoDepartment of Endocrinology and Metabolism, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430015, China.
Yaqin ZhanDepartment of Child Health, Maternal and Child Health Care Hospital of Hainan Province, Haikou 570206, China.
Mingjuan DaiDepartment of Pediatrics, Hangzhou First People's Hospital, Hangzhou 310022, China.
Guimei LiDepartment of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Li LiDepartment of Pediatrics, The 1st People's Hospital of Yunnan Province, Kunming 650032, China.
Yanjie LiuDepartment of Pediatrics, Inner Mongolia People's Hospital, Hohhot Inner Mongolia 010017, China.
Kan WangDepartment of Pediatrics, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China.
Yanfeng XiaoDepartment of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710004, China.
Xingxing ZhangDepartment of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
Junhua DongDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, China.
Zaiyan GuDepartment of Pediatrics, Jiaxing First Hospital, Jiaxing 314000, China.
Lirong YingDepartment of Pediatrics, Cixi People's Hospital, Cixi 315300, China.
Feng HuangDepartment of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226000, China.
Yanling LiuDepartment of Pediatrics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Zheng LiuDepartment of Pediatrics, Tai'an Maternal and Child Health Care Hospital, Tai'an, Shandong 271000, China.
Jin YeDepartment of Pediatrics, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.
Dongmei ZhaoPediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
Xu HuDepartment of Pediatrics, Lu'an People's Hospital, Lu'an 237000, China.
Zhihong JiangDepartment of Pediatric, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang 471003, China.
Kan YeDepartment of Child Health, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China.
Hong ZhuDepartment of Pediatrics, The First People's Hospital of Changzhou, Changzhou 213000, China.
Shaoke ChenDepartment of Pediatrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530005, China.
Xiaobo ChenDepartment of Endocrinology, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
Naijun WanDepartment of Pediatrics, Jishuitan Hospital, Beijing 100035, China.
Zhuangjian XuDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi 214122, China.
Qingjin YinWard 1, Department of Internal Medicine, Chengdu Children's Specialized Hospital, Chengdu 610015, China.
Hongxiao ZhangDepartment of Pediatric, Second Hospital of Lanzhou University, Lanzhou 730030, China.
Xiaodong HuangDepartment of Endocrinology and Genetics, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Jianying YinDepartment of Pediatrics, Hebei General Hospital, Shijiazhuang 050051, China.
Huifeng ZhangDepartment of Pediatrics, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Pin LiDepartment of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200333, China.
Ping YinSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Junfen FuDepartment of Endocrinology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.ORCID 0000-0001-6405-1251
XiaoPing LuoDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0002-3748-4817
Nanchang University · CNCentral South University · CNZhejiang Provincial People's Hospital · CNChildren's Hospital of Zhejiang University · CNGuangxi Medical University · CNHebei Medical University · CNPeking University · CNShanghai Jiao Tong University · CNSun Yat-sen University · CNChengdu Women's and Children's Central Hospital · CNFirst Affiliated Hospital of Henan University of Science and Technology · CNFirst Hospital of Jiaxing · CNHainan Maternal and Child Health Hospital · CNHospital of Hebei Province · CNJiangnan University · CNQingdao University · CNShandong University · CNSichuan University · CNZhejiang University · CNAir Force Medical University · CN
Funding
The National Key Research and Development Program of China is funded by Ministry of Science and Technology of the People's Republic of China 2018YFC1002400The Special Science and Technology Major Project of Hubei Province is funded by Hubei Provincial Science and Technology Department ZDZX2020000020
Abstract
contextThe evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited.
objectiveThis study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the real world, as well as to examine the effects of dose on patient outcomes.
designA prospective, observational, posttrial study (NCT03290235). SETTING, PARTICIPANTS AND
interventionChildren with GHD were enrolled from 81 centers in China in 4 individual clinical trials and received weekly 0.2 mg/kg/wk (high-dose) or 0.1 to <0.2 mg/kg/wk (low-dose) PEG-rhGH for 30 months. MAIN OUTCOMES MEASURES: Height SD score (Ht SDS) at 12, 24, and 36 months.
resultsA total of 1170 children were enrolled in this posttrial study, with 642 patients in the high-dose subgroup and 528 in the low-dose subgroup. The Ht SDS improved significantly after treatment in the total population (P < 0.0001), with a mean change of 0.53 ± 0.30, 0.89 ± 0.48, 1.35 ± 0.63, 1.63 ± 0.75 at 6 months, 12 months, 24 months, and 36 months, respectively. In addition, the changes in Ht SDS from baseline were significantly improved in the high-dose subgroup compared with the low-dose subgroup at 6, 12, 24, and 36 months after treatment (all P < 0.05). A total of 12 (1.03%) patients developed serious adverse events. There was no serious adverse event related to the treatment, and no AEs leading to treatment discontinuation or death occurred.
conclusionsPEG-rhGH showed long-term effectiveness and safety in treating children with GHD. Both dose subgroups showed promising outcomes, whereas PEG-rhGH 0.2 mg/kg/wk might show additional benefit.
Indexed as
Dwarfism, PituitaryHuman Growth HormoneChildGrowth DisordersHumansInsulin-Like Growth Factor IPolyethylene GlycolsProspective StudiesRecombinant ProteinsHuman Growth HormoneInsulin-Like Growth Factor IPolyethylene GlycolsRecombinant Proteinsgrowth hormone deficiencyJintrolonglong-acting growth hormonePEGylated recombinant human growth hormone
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Registered trials
NCT03290235ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.