Evidence map›Paper›PMID 36669484›Full record

ArticleCell2023

All-optical physiology resolves a synaptic basis for behavioral timescale plasticity.

Linlin Z Fan, Doo Kyung Kim, Joshua H Jennings, He Tian, Peter Y Wang, Charu Ramakrishnan, Sawyer Randles, Yanjun Sun, Elina Thadhani, Yoon Seok Kim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed.

  1. Article
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  8. Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026
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  13. Article
  14. Review
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  17. Article
  18. Article
  19. Article
  20. Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Linlin Z FanDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Doo Kyung KimDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Joshua H JenningsDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
He TianDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Peter Y WangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Sawyer RandlesDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Yanjun SunDepartment of Neurobiology, Stanford University, Stanford, CA, USA.
Elina ThadhaniDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Yoon Seok KimDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Sean QuirinDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Lisa GiocomoDepartment of Neurobiology, Stanford University, Stanford, CA, USA.
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA; Department of Physics, Harvard University, Cambridge, MA, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford, CA, USA. Electronic address: deissero@stanford.edu.

Funding

OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALESR01MH086373 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2010 to 2025
$9.1M
Brain-wide correlation of single-cell firing properties to patterns of gene expressionRF1MH117042 · NIMH · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2018 to 2018
$1.2M
Howard Hughes Medical InstituteNIMH NIH HHS R01 MH086373NIMH NIH HHS RF1 MH117042
6 · The paper itself

Abstract

Learning has been associated with modifications of synaptic and circuit properties, but the precise changes storing information in mammals have remained largely unclear. We combined genetically targeted voltage imaging with targeted optogenetic activation and silencing of pre- and post-synaptic neurons to study the mechanisms underlying hippocampal behavioral timescale plasticity. In mice navigating a virtual-reality environment, targeted optogenetic activation of individual CA1 cells at specific places induced stable representations of these places in the targeted cells. Optical elicitation, recording, and modulation of synaptic transmission in behaving mice revealed that activity in presynaptic CA2/3 cells was required for the induction of plasticity in CA1 and, furthermore, that during induction of these place fields in single CA1 cells, synaptic input from CA2/3 onto these same cells was potentiated. These results reveal synaptic implementation of hippocampal behavioral timescale plasticity and define a methodology to resolve synaptic plasticity during learning and memory in behaving mammals.

Indexed as

CA1 Region, HippocampalHippocampusAnimalsLearningMammalsMiceNeuronal PlasticityNeuronsSynaptic Transmissionall-optical electrophysiologyexcitabilityhippocampal behavioral timescale plasticityimagingoptogeneticsplace cellssynaptic plasticity

Identifiers

PMID36669484
PMCPMC10327443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.