Evidence map›Paper›PMID 36669138›Full record

ArticleACS infectious diseases2023

Chemical Optimization of Selective

Martin J Everett, David T Davies, Simon Leiris, Nicolas Sprynski, Agustina Llanos, Jérôme M Castandet, Clarisse Lozano, Christopher N LaRock, Doris L LaRock, Giuseppina Corsica and 6 more

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Temperature-dependent reprogramming of virulence traits duringbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Exploring the Role ofACS infectious diseases · 2026
    Article
  4. mSphere · 2026
    Article
  5. Article
  6. Multiparameter Optimization ofJournal of medicinal chemistry · 2026
    Article
  7. Article
  8. Review
  9. Airway mucus in infection.Frontiers in physiology · 2026
    Review
  10. Article
  11. Identification of novelRSC medicinal chemistry · 2025
    Article
  12. bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Mutation ofMicrobiology spectrum · 2024
    Article
  19. A Supramolecular Antibiotic Targeting Drug-ResistantACS applied materials & interfaces · 2024
    Article
  20. Inhibition ofJournal of microbiology and biotechnology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 4 countries.

Martin J EverettAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.ORCID 0000-0003-2002-1805
David T DaviesAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.ORCID 0000-0001-7392-4886
Simon LeirisAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.
Nicolas SprynskiAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.ORCID 0000-0001-8165-6949
Agustina LlanosAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.
Jérôme M CastandetAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.ORCID 0000-0002-6298-6384
Clarisse LozanoAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.
Christopher N LaRockDepartment of Microbiology and Immunology, Rollins Research Center, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.ORCID 0000-0003-3035-5331
Doris L LaRockDepartment of Microbiology and Immunology, Rollins Research Center, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.
Giuseppina CorsicaDipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Viale Bracci 16, 53100 Siena, Italy.
Jean-Denis DocquierDipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Viale Bracci 16, 53100 Siena, Italy.
Thomas D PallinCharles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K.ORCID 0000-0001-5153-7965
Andrew CridlandCharles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K.
Toby BlenchCharles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K.ORCID 0000-0002-7401-9199
Magdalena ZalacainAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.
Marc LemonnierAntabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.ORCID 0000-0002-8587-9864
Charles River Laboratories (United Kingdom) · GBRollins College · USUniversity of Siena · IT

Funding

NIEHS NIH HHS 27302C0028Wellcome Trust
6 · The paper itself

Abstract

LasB elastase is a broad-spectrum exoprotease and a key virulence factor of

Indexed as

Pseudomonas aeruginosaVirulence FactorsAnimalsInterleukin-1betaKineticsMiceModels, AnimalPancreatic ElastaseIL1B protein, mouseInterleukin-1betaPancreatic ElastaseVirulence FactorsantivirulenceelastaseIL-1βLasBpseudolysinPseudomonas aeruginosa

Identifiers

PMID36669138
PMCPMC9926489
OpenAlexW4317564880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.