ArticleProceedings of the National Academy of Sciences of the United States of America2023
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450851 (Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network), which is not on this map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Communications biology · 2026Article
- Integrated ERK-PKA-YAP/TAZ-SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets.Frontiers in cell and developmental biology · 2026Review
- Article
- Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes.medRxiv : the preprint server for health sciences · 2025Article
- The Principle of Cortical Development and Evolution.Neuroscience bulletin · 2025Review
- The Control of Cortical Folding: Multiple Mechanisms, Multiple Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Rare variation in non-coding regions with evolutionary signatures contributes to autism spectrum disorder risk.Cell genomics · 2024Article
- Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Genomic regions, candidate genes, and pleiotropic variants associated with physiological and anatomical indicators of heat stress response in lactating sows.BMC genomics · 2024Article
- The clinical utility and diagnostic implementation of human subject cell transdifferentiation followed by RNA sequencing.American journal of human genetics · 2024Article
- Article
- Shaping the brain: The emergence of cortical structure and folding.Developmental cell · 2023Review
- Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria.JAMA neurology · 2023Article
- Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- TMEM161B modulates radial glial scaffolding in neocortical development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 9 institutions in 4 countries.
Shyam K AkulaDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0003-2334-591X
Jack H MarcianoDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-0238-9916
Youngshin LimDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-7842-3244
David Exposito-AlonsoDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-4950-2744
Norma K HyltonDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Grace H HwangDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.ORCID 0000-0002-4979-4409
Jennifer E NeilDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Nicole DominadoDepartment of Anatomy & Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.
Rosie K Bunton-StasyshynMary Lyon Centre, United Kingdom Medical Research Council Harwell, Didcot, Oxfordshire, OX11 0RD, UK.ORCID 0000-0002-1895-2240
Janet H T SongDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Maya TalukdarDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-5997-5633
Aloisia SchmidDepartment of Physics/Electron Microscopy Core, Northeastern University, Boston, MA 02115.
Lydia TeboulMary Lyon Centre, United Kingdom Medical Research Council Harwell, Didcot, Oxfordshire, OX11 0RD, UK.
Alisa MoDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-6435-1227
Taehwan ShinDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Benjamin FinanderDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Samantha G BeckDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Rebecca C YehDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Aoi OtaniDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Xuyu QianDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.
Ellen M DeGennaroDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0001-5506-6451
Fowzan S AlkurayaDepartment of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, 11564 Riyadh, Saudi Arabia.
Sateesh MaddirevulaDepartment of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, 11564 Riyadh, Saudi Arabia.
Gregory D CascinoDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.ORCID 0000-0002-5380-2977
Caterina GianniniDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.ORCID 0000-0003-2757-6782
Undiagnosed Diseases Network
Lindsay C BurrageDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-5108-8861
Jill A RosenfieldDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-5664-7987
Shamika KetkarDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Gary D ClarkDepartments of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Carlos BacinoDepartments of Pediatrics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-4342-5012
Richard A LewisDepartments of Pediatrics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-6644-6385
Rosalind A SegalDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.ORCID 0000-0001-9850-8432
J Fernando BazanUnit for Structural Biology, Vlaams Instituut voor Biotechnologie-UGent Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0002-3645-9935
Kelly A SmithDepartment of Anatomy & Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0002-8283-9760
Jeffrey A GoldenDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0000-0001-9933-5502
Ginam ChoDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0000-0002-7262-8716
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-0156-2238
Boston Children's Hospital · USBaylor College of Medicine · USCedars-Sinai Medical Center · USHarvard University · USThe University of Melbourne · AUMedical Research Council · GBMayo Clinic · USMayo Clinic in Arizona · USNortheastern University · US
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MTraining in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5MJoint Center for Mendelian GenomicsUM1HG008900 · NHGRI · BROAD INSTITUTE, INC. · PI O'DONNELL-LURIA, ANNE, REHM, HEIDI L · 2016 to 2020
$16.5MPHD TRAINING IN NEUROSCIENCET32MH020017 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JOHN ASSAD · 1997 to 2026
$15.8MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MPilot of New Technologies to Increase the Genomic Diagnosis of Undiagnosed Disease Network (UDN) PatientsU01HG007709 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BACINO, CARLOS A., LEE, BRENDAN · 2014 to 2022
$14.3MHUMAN EPILEPSY GENETICS--NEURONAL MIGRATION DISORDERSR01NS035129 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WALSH, CHRISTOPHER A. · 1997 to 2023
$9.5MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MNeuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8MArx Associated Transcriptional Networks in Neocortical DevelopmentR01NS100007 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI GOLDEN, JEFFREY A · 2018 to 2021
$1.5MHoward Hughes Medical InstituteMedical Research Council MC_UP_1502/3Medical Research Council MC_UP_2201/1NCI NIH HHS P30 CA015083NHGRI NIH HHS U01 HG007709NHGRI NIH HHS UM1 HG006348NHGRI NIH HHS UM1 HG008900NIA NIH HHS T32 AG000222NIBIB NIH HHS T32 EB001680NICHD NIH HHS P50 HD105351NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIMH NIH HHS T32 MH020017NINDS NIH HHS R01 NS035129NINDS NIH HHS R01 NS100007
Abstract
Sonic hedgehog signaling regulates processes of embryonic development across multiple tissues, yet factors regulating context-specific Shh signaling remain poorly understood. Exome sequencing of families with polymicrogyria (disordered cortical folding) revealed multiple individuals with biallelic deleterious variants in
Indexed as
FerretsHedgehog ProteinsAnimalsCentral Nervous SystemCiliaFemaleHumansMembrane ProteinsMiceMice, KnockoutPregnancySignal TransductionHedgehog ProteinsMembrane ProteinsTmem161b protein, mousecortical gyrationholoprosencephalypolymicrogyriaprimary ciliaSonic Hedgehog
Identifiers
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Read underepoch 390
Registered trials
NCT02450851ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.