Evidence map›Paper›PMID 36669057›Full record

ReviewVeterinary sciences2023

Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects.

Shereen Basiouni, Guillermo Tellez-Isaias, Juan D Latorre, Brittany D Graham, Victor M Petrone-Garcia, Hesham R El-Seedi, Sakine Yalçın, Amr Abd El-Wahab, Christian Visscher, Helen L May-Simera and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Veterinary sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
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  11. Review
  12. Article
  13. Article
  14. Phytogenic feed additive derived fromOpen veterinary journal · 2025
    Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 7 countries.

Shereen BasiouniInstitute of Molecular Physiology, Johannes-Gutenberg University, 55128 Mainz, Germany.ORCID 0000-0003-0990-7912
Guillermo Tellez-IsaiasDepartment of Poultry Science, University of Arkansas Agricultural Experiment Station, Fayetteville, AR 72701, USA.ORCID 0000-0002-2416-2747
Juan D LatorreDepartment of Poultry Science, University of Arkansas Agricultural Experiment Station, Fayetteville, AR 72701, USA.ORCID 0000-0001-6250-566X
Brittany D GrahamDepartment of Poultry Science, University of Arkansas Agricultural Experiment Station, Fayetteville, AR 72701, USA.ORCID 0000-0001-8021-716X
Victor M Petrone-GarciaFacultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico (UNAM), Cuautitlan Izcalli 58190, Mexico.ORCID 0000-0001-6109-6366
Hesham R El-SeediPharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, SE 751 24 Uppsala, Sweden.
Sakine YalçınDepartment of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Ankara University (AU), 06110 Ankara, Turkey.ORCID 0000-0001-8640-2729
Amr Abd El-WahabInstitute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hanover, Germany.ORCID 0000-0002-2947-6737
Christian VisscherInstitute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hanover, Germany.ORCID 0000-0003-1497-5709
Helen L May-SimeraInstitute of Molecular Physiology, Johannes-Gutenberg University, 55128 Mainz, Germany.
Claudia HuberStructural Biochemistry of Membranes, Bavarian NMR Center, Technical University of Munich (TUM), D-85747 Garching, Germany.ORCID 0000-0002-1204-8162
Wolfgang EisenreichStructural Biochemistry of Membranes, Bavarian NMR Center, Technical University of Munich (TUM), D-85747 Garching, Germany.ORCID 0000-0002-9832-8279
Awad A ShehataAvian and Rabbit Diseases Department, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Egypt.ORCID 0000-0001-5260-0778
Arkansas Agricultural Experiment Station · USJohannes Gutenberg University Mainz · DETechnical University of Munich · DEAnkara University · TRJiangsu University · CNMansoura University · EGUniversidad de Cuautitlán Izcalli · MXUniversity of Sadat City · EGUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

BMBF 031B0823D; 01DH21010A, 01DH21010B, and 01DH21010C
6 · The paper itself

Abstract

Chronic stress is recognized as a secret killer in poultry. It is associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative stress reactions that damage the barrier function of the cells lining the gut wall. Poultry, especially the genetically selected broiler breeds, frequently suffer from these chronic stress symptoms when exposed to multiple stressors in their growing environments. Since oxidative stress reactions and inflammatory damages are multi-stage and long-term processes, overshooting immune reactions and their down-stream effects also negatively affect the animal's microbiota, and finally impair its performance and commercial value. Means to counteract oxidative stress in poultry and other animals are, therefore, highly welcome. Many phytogenic substances, including flavonoids and phenolic compounds, are known to exert anti-inflammatory and antioxidant effects. In this review, firstly, the main stressors in poultry, such as heat stress, mycotoxins, dysbiosis and diets that contain oxidized lipids that trigger oxidative stress and inflammation, are discussed, along with the key transcription factors involved in the related signal transduction pathways. Secondly, the most promising phytogenic substances and their current applications to ameliorate oxidative stress and inflammation in poultry are highlighted.

Indexed as

inflammationoxidative stressphytogenic substancespoultrystressors

Identifiers

PMID36669057
PMCPMC9866488
OpenAlexW4316468331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.