Evidence map›Paper›PMID 36668862›Full record

ArticleToxins2023

Evaluation of the Synthetic Multifunctional Peptide Hp-MAP3 Derivative of Temporin-PTa.

Patrícia Souza E Silva, Alexya Sandim Guindo, Pedro Henrique Cardoso Oliveira, Luiz Filipe Ramalho Nunes de Moraes, Ana Paula de Araújo Boleti, Marcos Antonio Ferreira, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Luana Rossato, Simone Simionatto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Patrícia Souza E SilvaS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.
Alexya Sandim GuindoS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.
Pedro Henrique Cardoso OliveiraS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.ORCID 0000-0002-2872-3767
Luiz Filipe Ramalho Nunes de MoraesS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.ORCID 0000-0003-0716-5062
Ana Paula de Araújo BoletiS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.
Marcos Antonio FerreiraS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.
Caio Fernando Ramalho de OliveiraLaboratório de Purificação de Proteínas e suas Funções Biológicas, Unidade de Tecnologia de Alimentos e da Saúde Pública, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, Mato Grosso do Sul, Brazil.ORCID 0000-0001-9549-4848
Maria Ligia Rodrigues MacedoLaboratório de Purificação de Proteínas e suas Funções Biológicas, Unidade de Tecnologia de Alimentos e da Saúde Pública, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, Mato Grosso do Sul, Brazil.ORCID 0000-0001-6969-6307
Luana RossatoLaboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados UFGD, Dourados 79825-070, Mato Grosso do Sul, Brazil.ORCID 0000-0002-6115-3313
Simone SimionattoLaboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados UFGD, Dourados 79825-070, Mato Grosso do Sul, Brazil.ORCID 0000-0003-2367-0915
Ludovico MiglioloS-Inova Biotech, Postgraduate Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, Mato Grosso do Sul, Brazil.
Universidade Católica Dom Bosco · BRUniversidade Federal da Grande Dourados · BRUniversidade Federal de Mato Grosso do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, antimicrobial peptides isolated from amphibian toxins have gained attention as new multifunctional drugs interacting with different molecular targets. We aimed to rationally design a new peptide from temporin-PTa. Hp-MAP3 (NH

Indexed as

Amphibian ProteinsAntimicrobial Cationic PeptidesAmino Acid SequenceAnimalsAnti-Bacterial AgentsCircular DichroismEscherichia coliHumansMiceMicrobial Sensitivity TestsRanidaeStaphylococcus aureusAmphibian ProteinsAnti-Bacterial AgentsAntimicrobial Cationic Peptidestemporinantimicrobial peptidesbacterial resistancefungal infectionsrational designtemporins

Identifiers

PMID36668862
PMCPMC9866994
OpenAlexW4313572025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.