Evidence map›Paper›PMID 36668846›Full record

ArticleToxins2022

Citrinin Exposure in Germany: Urine Biomarker Analysis in Children and Adults.

Gisela H Degen, Jörg Reinders, Martin Kraft, Wolfgang Völkel, Felicia Gerull, Rafael Burghardt, Silvia Sievering, Jennifer Engelmann, Yvonni Chovolou, Jan G Hengstler and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  6. The MAK collection for occupational health and safety · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Gisela H DegenLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, D-44139 Dortmund, Germany.ORCID 0000-0002-5034-6195
Jörg ReindersLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, D-44139 Dortmund, Germany.ORCID 0000-0003-1025-7849
Martin KraftState Agency for Nature, Environment and Consumer Protection North-Rhine Westphalia, Department of Environmental Medicine, Wallneyer Straße 6, D-45133 Essen, Germany.ORCID 0000-0002-3969-8157
Wolfgang VölkelBavarian Health and Food Safety Authority, Department of Chemical Safety, Toxicology and Exposure Monitoring, Pfarrstraße 3, D-80538 München, Germany.
Felicia GerullLandeslabor Berlin-Brandenburg, Fachbereich IV-4, Umweltbezogener Gesundheitsschutz, Rudower Chaussee 39, D-12489 Berlin, Germany.
Rafael BurghardtLandeslabor Berlin-Brandenburg, Fachbereich IV-4, Umweltbezogener Gesundheitsschutz, Rudower Chaussee 39, D-12489 Berlin, Germany.
Silvia SieveringState Agency for Nature, Environment and Consumer Protection North-Rhine Westphalia, Department of Environmental Medicine, Wallneyer Straße 6, D-45133 Essen, Germany.
Jennifer EngelmannState Agency for Nature, Environment and Consumer Protection North-Rhine Westphalia, Department of Environmental Medicine, Wallneyer Straße 6, D-45133 Essen, Germany.
Yvonni ChovolouState Agency for Nature, Environment and Consumer Protection North-Rhine Westphalia, Department of Environmental Medicine, Wallneyer Straße 6, D-45133 Essen, Germany.ORCID 0000-0002-6324-0883
Jan G HengstlerLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, D-44139 Dortmund, Germany.
Hermann FrommeInstitut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Klinikum der Ludwig-Maximilians-Universität München, Ziemssenstraße 1, D-80336 München, Germany.
Ministry for Environment, Agriculture, Conservation and Consumer Protection · DETU Dortmund University · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Citrinin (CIT), a mycotoxin known to exert nephrotoxicity, is a contaminant in food and feed. Since CIT contamination is not regularly analyzed, data on its occurrence and especially levels in food commodities are insufficient for conducting a conventional exposure assessment. Yet, human biomonitoring, i.e., an analysis of CIT and its metabolite dihydrocitrinone (DH-CIT) in urine samples allows to estimate exposure. This study investigated CIT exposure in young (2-14 years) and adult (24-61 years) residents of three federal states in Germany. A total of 179 urine samples from children and 142 from adults were collected and analyzed by a targeted LC-MS/MS based method for presence of CIT and DH-CIT. At least one of the biomarkers was detected and quantified in all urines, which indicated a widespread dietary exposure to the mycotoxin in Germany. Interestingly, the biomarker concentrations of CIT

Indexed as

CitrininBiomarkersChildChromatography, LiquidFood ContaminationGermanyHumansTandem Mass SpectrometryBiomarkersCitrininbiomonitoringcitrinindihydrocitrinoneexposuremycotoxinnephrotoxin

Identifiers

PMID36668846
PMCPMC9862099
OpenAlexW4313361197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.