Evidence map›Paper›PMID 36668785›Full record

ArticleToxics2023

Size-Resolved Redox Activity and Cytotoxicity of Water-Soluble Urban Atmospheric Particulate Matter: Assessing Contributions from Chemical Components.

Athanasios Besis, Maria Pia Romano, Eleni Serafeim, Anna Avgenikou, Athanasios Kouras, Maria Giulia Lionetto, Maria Rachele Guascito, Anna Rita De Bartolomeo, Maria Elena Giordano, Annarosa Mangone and 2 more

Abstract read
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Athanasios BesisEnvironmental Pollution Control Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0003-3225-2555
Maria Pia RomanoDepartment of Mathematics and Physics, University of Salento, 73100 Lecce, Italy.
Eleni SerafeimEnvironmental Pollution Control Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Anna AvgenikouEnvironmental Pollution Control Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Athanasios KourasEnvironmental Pollution Control Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-9564-0160
Maria Giulia LionettoDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.ORCID 0000-0003-3752-0192
Maria Rachele GuascitoDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.ORCID 0000-0002-3399-4983
Anna Rita De BartolomeoDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.
Maria Elena GiordanoDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.
Annarosa MangoneDepartment of Chemistry, University of Bari Aldo Moro, 70124 Bari, Italy.
Daniele ContiniInstitute of Atmospheric Sciences and Climate (CNR-ISAC), 73100 Lecce, Italy.ORCID 0000-0003-4454-0642
Constantini SamaraEnvironmental Pollution Control Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0003-2590-2716

Funding

State Scholarships Foundation MIS-5033021This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project "Reinforcement of Postdoctoral Researc MIS-5033021
6 · The paper itself

Abstract

Throughout the cold and the warm periods of 2020, chemical and toxicological characterization of the water-soluble fraction of size segregated particulate matter (PM) (<0.49, 0.49−0.95, 0.95−1.5, 1.5−3.0, 3.0−7.2 and >7.2 μm) was conducted in the urban agglomeration of Thessaloniki, northern Greece. Chemical analysis of the water-soluble PM fraction included water-soluble organic carbon (WSOC), humic-like substances (HULIS), and trace elements (V, Cr, Mn, Fe, Ni, Cu, Zn, As, Cd and Pb). The bulk (sum of all size fractions) concentrations of HULIS were 2.5 ± 0.5 and 1.2 ± 0.3 μg m−3, for the cold and warm sampling periods, respectively with highest values in the <0.49 μm particle size fraction. The total HULIS-C/WSOC ratio ranged from 17 to 26% for all sampling periods, confirming that HULIS are a significant part of WSOC. The most abundant water-soluble metals were Fe, Zn, Cu, and Mn. The oxidative PM activity was measured abiotically using the dithiothreitol (DTT) assay. In vitro cytotoxic responses were investigated using mitochondrial dehydrogenase (MTT). A significant positive correlation was found between OPmDTT, WSOC, HULIS and the MTT cytotoxicity of PM. Multiple Linear Regression (MLR) showed a good relationship between OPMDTT, HULIS and Cu.

Indexed as

DTT assayHULISMTT assaywater soluble elementsWSOC

Identifiers

PMID36668785
PMCPMC9867266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.