Evidence map›Paper›PMID 36668736›Full record

ArticleToxics2022

Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort.

Kyle Dack, Robyn E Wootton, Caroline M Taylor, Sarah J Lewis

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Kyle DackMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.ORCID 0000-0003-0319-590X
Robyn E WoottonNic Waals Institute, Lovisenberg Diaconal Hospital, 0771 Oslo, Norway.
Caroline M TaylorCentre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol BS8 1NU, UK.ORCID 0000-0001-8347-5092
Sarah J LewisMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.ORCID 0000-0003-4311-6890
University of Bristol · GB

Funding

Medical Research Council 217065/Z/19/ZMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MR/T010010/1MRC Integrative Epidemiology Unit MC_UU_00011/1NIHR Bio-medical Research Centre at University Hospitals Bristol NASouth-Eastern Regional Health Authority 2020024Wellcome Trust
6 · The paper itself

Abstract

Mercury is highly toxic metal found in trace quantities in common foods. There is concern that exposure during pregnancy could impair infant development. Epidemiological evidence is mixed, but few studies have examined postnatal growth. Differences in nutrition, exposures, and the living environment after birth may make it easier to detect a negative impact from mercury toxicity on infant growth. This study includes 544 mother-child pairs from the Avon Longitudinal Study of Parents and Children. Blood mercury was measured in early pregnancy and infant weight at 10 intervals between 4 and 61 months. Mixed-effect models were used to estimate the change in infant weight associated with prenatal mercury exposure. The estimated difference in monthly weight gain was -0.02 kg per 1 standard deviation increase in Hg (95% confidence intervals: -0.10 to 0.06 kg). When restricted to the 10th decile of Hg, the association with weight at each age level was consistently negative but with wide confidence intervals. The lack of evidence for an association may indicate that at Hg levels in this cohort (median 1.9 µg/L) there is minimal biological impact, and the effect is too small to be either clinically relevant or detectable.

Indexed as

ALSPACbirth cohortmercurypostnatal growthpregnancy

Identifiers

PMID36668736
PMCPMC9864311
OpenAlexW4312174328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.