ArticleScience advances2023
Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- A Structurally CharacterizedAntioxidants (Basel, Switzerland) · 2026Article
- Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa.Nature communications · 2026Article
- Targeting Apolipoprotein E4 rescues photoreceptor degeneration by inhibiting the disease-associated microglia activation in experimental retinal detachment.Journal of neuroinflammation · 2026Article
- Crop-OCT: a Fully Integrated Imageomics Pipeline to Identify Regional and Focal Retinopathy in Murine Models.bioRxiv : the preprint server for biology · 2026Article
- Targeted Ferroptosis Improves RPE Phagocytosis via MERTK/NFE2L2/HMOX1 Axis to Alleviate Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2026Article
- Increased Gut Microbiota Diversity in Patients With Retinitis Pigmentosa and Implications for Disease Phenotypes and Progression.Investigative ophthalmology & visual science · 2026Article
- Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients.Investigative ophthalmology & visual science · 2025Article
- Retinal Pigment Epithelium Extracellular Vesicles Induce Microglia Polarization in MERTK-Associated Retinal Degeneration.Investigative ophthalmology & visual science · 2025Article
- Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative Mechanisms.International journal of molecular sciences · 2025Article
- Genetic Analysis of Choroideremia-Related Rab Escort Proteins.International journal of molecular sciences · 2025Article
- Frontier applications of retinal nanomedicine: progress, challenges and perspectives.Journal of nanobiotechnology · 2025Review
- The role of inflammation in myopic retinopathy.Frontiers in ophthalmology · 2025Review
- TNF-alpha promotes cilia elongation via mixed lineage kinases signaling in mouse fibroblasts and human RPE-1 cells.Cytoskeleton (Hoboken, N.J.) · 2024Article
- IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2.Investigative ophthalmology & visual science · 2024Article
- In the Eyes of the Beholder-NewInternational journal of molecular sciences · 2024Review
- Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy.Frontiers in endocrinology · 2024Article
- Retinal atrophy, inflammation, phagocytic and metabolic disruptions develop in the MerTK-cleavage-resistant mouse model.Frontiers in neuroscience · 2024Article
- Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation.Immunological reviews · 2023Review
- Metabolism: How removal of damaged cells impacts energy availability in the retina.Current biology : CB · 2023Article
- Suppressor of cytokine signaling 3-derived peptide as a therapeutic for inflammatory and oxidative stress-induced damage to the retina.Molecular vision · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Maria E MercauDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-6971-8676
Yemsratch T AkaluDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-0829-7972
Francesca MazzoniCenter for Cancer, Genetic Diseases and Gene Regulation, Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.
Gavin GyimesiCenter for Cancer, Genetic Diseases and Gene Regulation, Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.ORCID 0000-0002-1615-1589
Emily J AlbertoDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Yong KongDepartment of Molecular Biophysics and Biochemistry, W. M. Keck Foundation Biotechnology Resource Laboratory, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-2881-5274
Brian P HaflerDepartment of Ophthalmology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Silvia C FinnemannCenter for Cancer, Genetic Diseases and Gene Regulation, Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.ORCID 0000-0001-9298-0736
Carla V RothlinDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-5693-5572
Sourav GhoshDepartment of Pharmacology, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-5990-8708
Yale University · USFordham University · USW. M. Keck Foundation · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1MAn innate immune checkpoint in cancer immunotherapy.R01CA212376 · NCI · YALE UNIVERSITY · PI GHOSH, SOURAV, ROTHLIN, CARLA · 2017 to 2021
$3.1MTargeting the inflammatory response in age-related macular degenerationR01EY034234 · NEI · YALE UNIVERSITY · PI Brian P Hafler · 2022 to 2026
$2.0MMolecular mechanisms of outer segment renewalR01EY026215 · NEI · FORDHAM UNIVERSITY · PI FINNEMANN, SILVIA C · 2016 to 2020
$2.0MNCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA212376NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY026215NEI NIH HHS R01 EY034234
Abstract
Severe, early-onset photoreceptor (PR) degeneration associated with
Indexed as
Retinal DegenerationRetinitis PigmentosaAnimalsc-Mer Tyrosine KinaseInflammationMiceProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesRetinal Pigment Epitheliumc-Mer Tyrosine KinaseMertk protein, mouseProto-Oncogene ProteinsReceptor Protein-Tyrosine Kinases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.