ArticlePloS one2023
Stability analysis of a multiscale model of cell cycle dynamics coupled with quiescent and proliferating cell populations.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cell Population Dynamics Informed by Cell-Cycle Regulation: A Deterministic Modeling Toolkit.Computational and structural biotechnology journal · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we perform a mathematical analysis of our proposed nonlinear, multiscale mathematical model of physiologically structured quiescent and proliferating cell populations at the macroscale and cell-cycle proteins at the microscale. Cell cycle dynamics (microscale) are driven by growth factors derived from the total cell population of quiescent and proliferating cells. Cell-cycle protein concentrations, on the other hand, determine the rates of transition between the two subpopulations. Our model demonstrates the underlying impact of cell cycle dynamics on the evolution of cell population in a tissue. We study the model's well-posedness, derive steady-state solutions, and find sufficient conditions for the stability of steady-state solutions using semigroup and spectral theory. Finally, we performed numerical simulations to see how the parameters affect the model's nonlinear dynamics.
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