ArticlePloS one2023
Better safe than sorry-Whole-genome sequencing indicates that missense variants are significant in susceptibility to COVID-19.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
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- Article
- Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination.NPJ vaccines · 2025Article
- Genetic Analysis and Predictive Modeling of COVID-19 Severity in a Hospital-Based Patient Cohort.Biomolecules · 2025Article
- The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization Analysis.Biomedicines · 2024Article
- Genomic determinants of antibody response to a typhoid vaccine in Indian recipients.Journal of genetics · 2024Article
- Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types.Advances in neurobiology · 2024Review
- MRBEE: A novel bias-corrected multivariable Mendelian Randomization method.bioRxiv : the preprint server for biology · 2023Article
- Shared genetic architecture of COVID-19 and Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Undoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified 18,191 significant SNPs for severe and 11,799 SNPs for resistant phenotype, showing that a great number of loci were significant in different COVID-19 representations. The majority of variants were synonymous (60.56% for severe, 58.46% for resistant phenotype) or located in introns (55.77% for severe, 59.83% for resistant phenotype). We identified the most significant SNPs for a severe outcome (in AJAP1 intron) and for COVID resistance (in FIG4 intron). We found no missense variants with a potential causal function on resistance to COVID-19; however, two missense variants were determined as significant a severe phenotype (in PM20D1 and LRP4 exons). None of the aforementioned SNPs and missense variants found in this study have been previously associated with COVID-19.
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Registered trials
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