Evidence map›Paper›PMID 36662804›Full record

ArticlePloS one2023

High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice.

Kelsey Teeple, Prabha Rajput, Maria Gonzalez, Yu Han-Hallett, Esteban Fernández-Juricic, Theresa Casey

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
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  7. Article
  8. Review
  9. Intermittent Fasting: Implications for Obesity-Related Colorectal Tumorigenesis.Endocrinology and metabolism clinics of North America · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Kelsey TeepleDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America.ORCID 0000-0002-3127-5002
Prabha RajputDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America.
Maria GonzalezDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America.ORCID 0000-0002-0853-8468
Yu Han-HallettBindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America.
Esteban Fernández-JuricicDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.
Theresa CaseyDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America.ORCID 0000-0002-8835-3550
Purdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurnal feeding pattern, weight gain, body composition, hair corticosterone levels and circadian patterns of fecal corticosterone. Prepubertal (~35d of age) ICR mice were assigned to control (CON; 10% fat) or high fat (HF; 60% fat) diet and fed for 4 wk to achieve obesity under 12h light and 12h of dark. Feed intake was measured twice daily to determine diurnal intake. Mice were weighed weekly. After 4 wk on diets hair was collected to measure corticosterone, crown-rump length was measured to calculate body mass index (BMI), and body composition was measured with EchoMRI to determine percent fat. HF mice weighed more (P<0.05) after week two, BMI and percent body fat was greater (P<0.05) in HF than CON at the end of wk 4. HF mice consumed more during the day (P<0.05) than CON mice after 1 week on diets. Hair corticosterone was higher in HF mice than in CON (P<0.05). Fecal circadian sampling over 48hr demonstrated that HF mice had elevated basal corticosterone, attenuated circadian rhythms, and a shift in amplitude. High fat feeding for diet induced obesity alters circadian eating pattern and corticosterone rhythms, indicating a need to consider the impact of circadian system disruption on reproductive competence.

Indexed as

CorticosteroneDiet, High-FatAnimalsCircadian RhythmDietEatingFeeding BehaviorFemaleMiceMice, Inbred ICRObesityCorticosterone

Identifiers

PMID36662804
PMCPMC9858401
OpenAlexW4317553683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.