SynthesisPloS one2023
Low pretreatment prognostic nutritional index predicts poor survival in breast cancer patients: A meta-analysis.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Association between malnutrition diagnosed by different screening and assessment tools and clinical outcomes: an umbrella review.Frontiers in nutrition · 2025Pooled it
- Prognostic value of Prognostic Nutritional Index in cancer: an umbrella review of systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Prognostic effect of the pretreatment prognostic nutritional index in cervical, ovarian, and endometrial cancer: a meta-analysis.BMC women's health · 2024Pooled it
- Association of prognostic nutritional index with prognostic outcomes in patients with glioma: a meta-analysis and systematic review.Frontiers in oncology · 2023Pooled it
- Prognostic and clinicopathological effect of the prognostic nutritional index (PNI) in patients with cervical cancer: a meta-analysis.Annals of medicine · 2023Pooled it
- Prognostic Impact of PET/CT-Derived Sarcopenia in Metastatic Breast Cancer Treated with CDK4/6 Inhibitors.Journal of clinical medicine · 2026Article
- Prognostic Factors Impacting Surgical Resection Outcomes in Elderly Patients With Brain Metastasis.The Kaohsiung journal of medical sciences · 2026Article
- The effects of prognostic nutritional index, systemic immune inflammation index and HALP score on fistula formation, recurrence and mortality in laryngeal cancer patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Article
- Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Index: Findings From PARADIGM-HF and PARAGON-HF.Journal of the American Heart Association · 2025Article
- A Prognostic Nutritional Index-Based Nomogram to Predict Breast Cancer Metastasis: A Retrospective Cohort Validation.Breast cancer (Dove Medical Press) · 2025Article
- Predictive and Prognostic Value of Inflammatory and Nutritional Indexes in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy.Medicina (Kaunas, Lithuania) · 2024Article
- The role of nutrition-based index in predicting survival of breast cancer patients: A systematic review and meta-analysis.Heliyon · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrognostic nutritional index (PNI), as an indicator of nutritional immune status, has been shown to be associated with therapeutic effects and survival of solid tumors. However, the prognostic role of PNI before treatment in human breast cancer (BC) is still not conclusive. Hence, we performed this meta-analysis to assess the value of it in prognosis prediction for BC patients. MATERIALS AND
methodsWe searched PubMed, Embase, Web of Science and EBSCO to identify the studies evaluating the association between PNI and survival such as overall survival (OS), disease-free survival (DFS) of BC, and computed extracted data into hazard ratios (HRs) for OS, DFS and clinicopathological features with STATA 12.0.
resultsA total of 2322 patients with BC from 8 published studies were incorporated into this meta-analysis. We discovered that low pretreatment PNI was significantly associated with worse OS, but not with DFS in BC patients. In stratified analyses, the result showed that decreased PNI before treatment was remarkably related with lower 3-year, 5-year, 8-year and 10-year OS, but not with 1-year survival rate in BC. In addition, although reduced PNI could not impact 1-year, 3-year or 5-year DFS, it considerably deteriorated 8-year and 10-year DFS in patients.
conclusionLow pretreatment PNI deteriorated OS, 8-year and 10-year DFS in BC patients, implicating that it is a valuable prognostic index and improving the nutritional immune status may offer a therapeutic strategy for these patients.
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