Evidence map›Paper›PMID 36662710›Full record

ArticlePloS one2023

Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates.

Lucas R Brenes, Alexander D Johnson, Matthew B Lohse

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. ThemBio · 2025
    Article
  2. Physiological adventures inMicrobiology and molecular biology reviews : MMBR · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lucas R BrenesDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.
Alexander D JohnsonDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.
Matthew B LohseDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0002-1071-781X
University of California, San Francisco · US

Funding

Regulatory Circuits and Virulence in Candida albicansR01AI049187 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSON, ALEXANDER D · 2001 to 2021
$13.1M
NIAID NIH HHS R01 AI049187
6 · The paper itself

Abstract

Candida albicans is a normal member of the human microbiome and an opportunistic fungal pathogen. This species undergoes several morphological transitions, and here we consider white-opaque switching. In this switching program, C. albicans reversibly alternates between two cell types, named "white" and "opaque," each of which is normally stable across thousands of cell divisions. Although switching under most conditions is stochastic and rare, certain environmental signals or genetic manipulations can dramatically increase the rate of switching. Here, we report the identification of two new inputs which affect white-to-opaque switching rates. The first, exposure to sub-micromolar concentrations of (E,E)-farnesol, reduces white-to-opaque switching by ten-fold or more. The second input, an inferred PKA phosphorylation of residue T208 on the transcriptional regulator Efg1, increases white-to-opaque switching ten-fold. Combining these and other environmental inputs results in a variety of different switching rates, indicating that a given rate represents the integration of multiple inputs.

Indexed as

Candida albicansFarnesolFungal ProteinsDNA-Binding ProteinsGene Expression Regulation, FungalGenetic TechniquesHumansPhenotypePhosphorylationTranscription FactorsDNA-Binding ProteinsEFG1 protein, Candida albicansFarnesolFungal ProteinsTranscription Factors

Identifiers

PMID36662710
PMCPMC9858334
OpenAlexW4317567853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.