Evidence map›Paper›PMID 36662618›Full record

ArticleCell reports2023

Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation.

David Liang, Liping Jiang, Sameer Ahmed Bhat, Sonia Missiroli, Mariasole Perrone, Angela Lauriola, Ritika Adhikari, Anish Gudur, Zahra Vasi, Ian Ahearn and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Crosstalk between protein lipidation and ubiquitination in tumor biology.Apoptosis : an international journal on programmed cell death · 2026
    Review
  2. Review
  3. ZDHHC5 and ZDHHC14 promote depression via the mediation of double-negative T cells.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  4. Review
  5. Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential.International journal of cardiology. Heart & vasculature · 2025
    Review
  6. Article
  7. RBM15-mediated mFrontiers in cell and developmental biology · 2025
    Review
  8. Review
  9. Geranylgeranylated SCFCell reports · 2024
    Article
  10. Geranylgeranylated-SCFbioRxiv : the preprint server for biology · 2024
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

David LiangDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA.
Liping JiangDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA.
Sameer Ahmed BhatDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA.
Sonia MissiroliDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Mariasole PerroneDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Angela LauriolaDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.
Ritika AdhikariDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA.
Anish GudurDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA.
Zahra VasiDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA.
Ian AhearnDepartment of Dermatology and Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Daniele GuardavaccaroDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.
Carlotta GiorgiDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Mark PhilipsDepartment of Medicine and Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Shafi KuchayDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, MBRB #1157, Chicago, IL 60607, USA. Electronic address: kuchay@uic.edu.
University of Illinois Chicago · USUniversity of Ferrara · ITNew York University · USUniversity of Verona · IT

Funding

Differential function and tumor vulnerabilities revealed by RAS membrane traffickingR35CA253178 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 2020 to 2026
$6.8M
Isoprenylcysteine Carboxyl Methyltransferase (ICMT) as a Target in NRAS Driven Melanoma - Resubmission - 1R01CA163489 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 2012 to 2020
$2.8M
Proteostasis at cellular membranes.R35GM137452 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Shafi M. Kuchay · 2020 to 2026
$2.6M
Role of nonsense mediated RNA decay in pancreatic cancerR01CA211687 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 2018 to 2022
$2.1M
NCI NIH HHS R01 CA163489NCI NIH HHS R01 CA211687NCI NIH HHS R35 CA253178NIGMS NIH HHS R35 GM137452
6 · The paper itself

Abstract

Substrate degradation by the ubiquitin proteasome system (UPS) in specific membrane compartments remains elusive. Here, we show that the interplay of two lipid modifications and PDE6δ regulates compartmental substrate targeting via the SCF

Indexed as

F-Box ProteinsCalciumLipidsLipoylationUbiquitinationCalciumF-Box ProteinsLipidscalcium homeostasiscell membranesCP: Cell biologyCP: Molecular biologyE3-ligasesoxidative stresspalmitoylationPDE6δprenylationprotein degradationtraffickingubiquitylation

Identifiers

PMID36662618
PMCPMC9988375
OpenAlexW4317469201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.