Evidence map›Paper›PMID 36662580›Full record

ReviewAnnual review of pharmacology and toxicology2023

Roadmap for Achieving Universal Antiretroviral Treatment.

Simiso Sokhela, Samanta Lalla-Edward, Mark J Siedner, Mohammed Majam, Willem Daniel Francois Venter

Abstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Antiretroviral Therapy-Associated Weight Gain in Mexico, a Country Prone to Comorbidities.International journal of health policy and management · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Simiso SokhelaEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; email: fventer@ezintsha.org.
Samanta Lalla-EdwardEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; email: fventer@ezintsha.org.
Mark J SiednerHarvard Medical School and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Mohammed MajamEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; email: fventer@ezintsha.org.
Willem Daniel Francois VenterEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; email: fventer@ezintsha.org.

Funding

Integrating HIV and hEART health in South Africa (iHeart-SA)UH3HL156388 · NHLBI · WITS HEALTH CONSORTIUM (PTY), LTD · PI ALI, MOHAMMED KUMAIL, MARCONI, VINCENT CHARLES · 2022 to 2024
$3.2M
Phase II study to evaluate the efficacy and safety of baricitinib for reduction of HIV in the central nervous systemR01MH128158 · NIMH · EMORY UNIVERSITY · PI Christina Gavegnano, Vincent Charles Marconi · 2022 to 2026
$3.2M
Integrating HIV and hEART health in South Africa (iHeart-SA)UG3HL156388 · NHLBI · WITS HEALTH CONSORTIUM (PTY), LTD · PI ALI, MOHAMMED KUMAIL, MARCONI, VINCENT CHARLES · 2020 to 2021
$1.7M
NHLBI NIH HHS UG3 HL156388NHLBI NIH HHS UH3 HL156388NIMH NIH HHS R01 MH128158
6 · The paper itself

Abstract

Modern antiretroviral therapy safely, potently, and durably suppresses human immunodeficiency virus (HIV) that, if left untreated, predictably causes acquired immunodeficiency syndrome (AIDS), which has been responsible for tens of millions of deaths globally since it was described in 1981. In one of the most extraordinary medical success stories in modern times, a combination of pioneering basic science, innovative drug development, and ambitious public health programming resulted in access to lifesaving, safe drugs, taken as an oral tablet daily, for most of the world. However, substantial challenges remain in the fields of prevention, timely access to diagnosis, and treatment, especially in pediatric and adolescent patients. As HIV-positive adults age, treating their comorbidities will require understanding the course of different chronic diseases complicated by HIV-related and antiretroviral toxicities and finding potential treatments. Finally, new long-acting antiretrovirals on the horizon promise exciting new options in both the prevention and treatment fields.

Indexed as

Acquired Immunodeficiency SyndromeAnti-HIV AgentsHIV InfectionsAdolescentAdultChildHumansAnti-HIV Agents90-90-90AIDSantiretroviralsHIVreconstitution

Identifiers

PMID36662580
PMCPMC10807407

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.