ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2023
High-density linkage maps and chromosome level genome assemblies unveil direction and frequency of extensive structural rearrangements in wood white butterflies (Leptidea spp.).
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 45 citations in OpenAlex.
- Article
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- Rapid genome modifications including chromosomal fusions and large-scale inversions are key features in Arctic codfish species.Genome biology · 2026Article
- First Chromosome-level Genome Assembly and Annotation of an Endangered Freshwater Stingray (Fontitrygon garouaensis) from Africa.Scientific data · 2026Article
- A high-quality draft genome assembly of the Neotropical butterfly, Batesia hypochlora (Nymphalidae: Biblidinae).BMC genomics · 2025Article
- Evolution of Hybrid Inviability Associated With Chromosome Fusions.Molecular ecology · 2025Article
- Genomics of Neotropical biodiversity indicators: Two butterfly radiations with rampant chromosomal rearrangements and hybridization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fusion, fission, and scrambling of the bilaterian genome in Bryozoa.Genome research · 2025Article
- Complex Genomic Landscape of Inversion Polymorphism in Europe's Most Destructive Forest Pest.Genome biology and evolution · 2024Article
- The holocentric chromosome microevolution: From phylogeographic patterns to genomic associations with environmental gradients.Molecular ecology · 2024Article
- Genomic hotspots of chromosome rearrangements explain conserved synteny despite high rates of chromosome evolution in a holocentric lineage.Molecular ecology · 2024Article
- Holocentric repeat landscapes: From micro-evolutionary patterns to macro-evolutionary associations with karyotype evolution.Molecular ecology · 2024Article
- The burst of satellite DNA in Leptidea wood white butterflies and their putative role in karyotype evolution.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Satellitome analysis on the pale-breasted thrush Turdus leucomelas (Passeriformes; Turdidae) uncovers the putative co-evolution of sex chromosomes and satellite DNAs.Scientific reports · 2024Article
- Rewinding the Ratchet: Rare Recombination Locally Rescues Neo-W Degeneration and Generates Plateaus of Sex-Chromosome Divergence.Molecular biology and evolution · 2024Article
- Whole-genome resequencing of tea grey geometrid provides insights into their population structure and adaptation to tea crops.Crop health · 2024Article
- Meiotic drive against chromosome fusions in butterfly hybrids.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2024Article
- Comparative genomics reveals the dynamics of chromosome evolution in Lepidoptera.Nature ecology & evolution · 2024Article
- Comparative Genomics Reveal Phylogenetic Relationship and Chromosomal Evolutionary Events of Eight Cervidae Species.Animals : an open access journal from MDPI · 2024Article
- A Chromosome-Level Genome Assembly and Annotation for the Clouded Apollo Butterfly (Parnassius mnemosyne): A Species of Global Conservation Concern.Genome biology and evolution · 2024Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Karyotypes are generally conserved between closely related species and large chromosome rearrangements typically have negative fitness consequences in heterozygotes, potentially driving speciation. In the order Lepidoptera, most investigated species have the ancestral karyotype and gene synteny is often conserved across deep divergence, although examples of extensive genome reshuffling have recently been demonstrated. The genus Leptidea has an unusual level of chromosome variation and rearranged sex chromosomes, but the extent of restructuring across the rest of the genome is so far unknown. To explore the genomes of the wood white (Leptidea) species complex, we generated eight genome assemblies using a combination of 10X linked reads and HiC data, and improved them using linkage maps for two populations of the common wood white (L. sinapis) with distinct karyotypes. Synteny analysis revealed an extensive amount of rearrangements, both compared to the ancestral karyotype and between the Leptidea species, where only one of the three Z chromosomes was conserved across all comparisons. Most restructuring was explained by fissions and fusions, while translocations appear relatively rare. We further detected several examples of segregating rearrangement polymorphisms supporting a highly dynamic genome evolution in this clade. Fusion breakpoints were enriched for LINEs and LTR elements, which suggests that ectopic recombination might be an important driver in the formation of new chromosomes. Our results show that chromosome count alone may conceal the extent of genome restructuring and we propose that the amount of genome evolution in Lepidoptera might still be underestimated due to lack of taxonomic sampling.
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