Evidence map›Paper›PMID 36662267›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

Acquired CFTR dysfunction and dense distribution of ionocytes in nasal mucosa of children with CRS.

Yang Han, Chao Jia, Tieshan Wang, Pengpeng Wang, Wenjing Liu, Yu Qin, Siyu Cai, Xiaojian Yang, Wei Zhang, Yuwei Liu and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  3. [Research progress on epithelial mucosal barrier impairment contributing to chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  4. Innate immune function in chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yang Han *Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Chao Jia *Department of Pathology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Tieshan Wang *Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Pengpeng WangDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Wenjing LiuDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Yu QinBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Siyu CaiCenter for Clinical Epidemiology and Evidence-Based Medicine, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Xiaojian YangDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Wei ZhangDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Yuwei LiuDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Xiao XiaoDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China.
Lejian HeDepartment of Pathology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Wentong GeDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China. gwt@bch.com.cn.ORCID http://orcid.org/0000-0002-2615-2702
Xin NiDepartment of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 NanLishi Road, Xicheng District, Beijing, 100045, China. nixin@bch.com.cn.
Capital Medical University · CNBeijing University of Chinese Medicine · CN

Funding

NCIRD CDC HHS HXZX-20210501
6 · The paper itself

Abstract

backgroundIonocytes are rare cells in airway epithelium characterized by a high expression of CFTR.

objectivesTo investigate the morphology and distribution of ionocytes and the function of CFTR in the nasal mucosal epithelium of children.

methodsThe exfoliated cells of nasal mucosa from 101 children were detected using flow cytometry to analyze the number of ionocytes and CFTR and the difference of CFTR function. Nasal mucosa and polyps were collected from 10 children with CRSwNP. The RNAscope of FOXI1 and CFTR was detected in pathological paraffin sections. The expression and distribution of ionocytes and CFTR in nasal mucosa and polyp epithelium were observed.

resultsIn CRS patients, the number of ionocytes in the nasal epithelium was lower and the number of ionocytes that did not express CFTR was higher, and the function of CFTR was also decreased. The expression of CFTR in the nasal mucosa of CRS showed the characteristics of local dense distribution and increased as the inflammation expanded. The ionocytes were "tadpole-shaped" in the epithelium and gathered in the area of high CFTR expression, the intracellular CFTR was expanded in clusters. Ionocytes that did not express CFTR was more common in the nasal polyps.

conclusionsThe number of ionocytes and the function of CFTR in nasal mucosa of CRS patients decreased. With the expansion of inflammation, CFTR and ionocytes showed more obvious dense distribution. Some ionocytes lost the expression of CFTR and did not show the "tadpole" shape, which may be related to the occurrence of polyps.

Indexed as

Nasal PolypsRhinitisSinusitisChildChronic DiseaseCystic Fibrosis Transmembrane Conductance RegulatorForkhead Transcription FactorsHumansInflammationNasal MucosaCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorForkhead Transcription FactorsFOXI1 protein, humanCFTRChildrenIonocytesNasal mucosaNasal polyps

Identifiers

PMID36662267
PMCPMC10220146
OpenAlexW4317542932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.