Evidence map›Paper›PMID 36662187›Full record

ReviewMarine drugs2022

Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering.

Qing He, Tianjian Tong, Chenxu Yu, Qun Wang

Abstract readReview
In one paragraph

Review in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Research Progress in Medical Biomaterials for Bone Infections.Journal of functional biomaterials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qing HeDepartment of Mechanical Engineering, Tufts University, Medford, MA 02155, USA.
Tianjian TongDepartment of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0002-0324-4671
Chenxu YuDepartment of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA 50011, USA.
Qun WangDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0002-5660-5602

Funding

Rational Design of Oral Drugs Targeting Mucosa DeliveryR21EB032991 · NIBIB · IOWA STATE UNIVERSITY · PI WANG, QUN · 2022 to 2024
$612k
NIBIB NIH HHS 1R21EB032991-01NIBIB NIH HHS R21 EB032991USDA-ARS 019636-00001USDA-NIFA 2016-07802
6 · The paper itself

Abstract

In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications.

Indexed as

AlginatesAlginic AcidBiocompatible MaterialsCell Culture TechniquesDrug Delivery SystemsHydrogelsTissue EngineeringAlginatesAlginic AcidBiocompatible MaterialsHydrogelsalgin/alginatealginate hybrid materials (AHMs)drug deliverytissue engineering

Identifiers

PMID36662187
PMCPMC9861007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.