Evidence map›Paper›PMID 36662087›Full record

ArticleJournal of functional biomaterials2023

Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices.

David Alexander Gregory, Annabelle T R Fricker, Peter Mitrev, Meghna Ray, Emmanuel Asare, Daniel Sim, Soponvit Larpnimitchai, Zixuan Zhang, Jinge Ma, Santosh S V Tetali and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David Alexander GregoryDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0003-2489-5462
Annabelle T R FrickerDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Peter MitrevDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Meghna RayDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Emmanuel AsareDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Daniel SimDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Soponvit LarpnimitchaiDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Zixuan ZhangDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Jinge MaDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.
Santosh S V TetaliDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0001-7122-2741
Ipsita RoyDepartment of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0001-5602-1714

Funding

3DBioNet NABBI/JU H2020 - PolyBioSkin 745839British Council Pakistan 006326/DIISB/007/2021
6 · The paper itself

Abstract

In the last few decades Additive Manufacturing has advanced and is becoming important for biomedical applications. In this study we look at a variety of biomedical devices including, bone implants, tooth implants, osteochondral tissue repair patches, general tissue repair patches, nerve guidance conduits (NGCs) and coronary artery stents to which fused deposition modelling (FDM) can be applied. We have proposed CAD designs for these devices and employed a cost-effective 3D printer to fabricate proof-of-concept prototypes. We highlight issues with current CAD design and slicing and suggest optimisations of more complex designs targeted towards biomedical applications. We demonstrate the ability to print patient specific implants from real CT scans and reconstruct missing structures by means of mirroring and mesh mixing. A blend of Polyhydroxyalkanoates (PHAs), a family of biocompatible and bioresorbable natural polymers and Poly(L-lactic acid) (PLLA), a known bioresorbable medical polymer is used. Our characterisation of the PLA/PHA filament suggest that its tensile properties might be useful to applications such as stents, NGCs, and bone scaffolds. In addition to this, the proof-of-concept work for other applications shows that FDM is very useful for a large variety of other soft tissue applications, however other more elastomeric MCL-PHAs need to be used.

Indexed as

3D printingbiomedical devicesPolyhydroxyalkanoatesregenerative medicinethermoplastic polymerstissue engineering

Identifiers

PMID36662087
PMCPMC9865795

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.