Evidence map›Paper›PMID 36662070›Full record

ReviewJournal of functional biomaterials2022

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review.

Maria E V Barreto, Rebeca P Medeiros, Adam Shearer, Marcus V L Fook, Maziar Montazerian, John C Mauro

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Maria E V BarretoNortheastern Laboratory for Evaluation and Development of Biomaterials (CERTBIO), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande 58429-900, PB, Brazil.ORCID 0000-0003-2319-7371
Rebeca P MedeirosNortheastern Laboratory for Evaluation and Development of Biomaterials (CERTBIO), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande 58429-900, PB, Brazil.ORCID 0000-0002-4526-5956
Adam ShearerDepartment of Materials Science and Engineering, The Pennsylvania State University, State College, PA 16802, USA.ORCID 0000-0002-4208-333X
Marcus V L FookNortheastern Laboratory for Evaluation and Development of Biomaterials (CERTBIO), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande 58429-900, PB, Brazil.
Maziar MontazerianNortheastern Laboratory for Evaluation and Development of Biomaterials (CERTBIO), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande 58429-900, PB, Brazil.ORCID 0000-0002-1409-9182
John C MauroDepartment of Materials Science and Engineering, The Pennsylvania State University, State College, PA 16802, USA.ORCID 0000-0002-4319-3530
Universidade Federal de Campina Grande · BRPennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds. Searching "bioactive glass gelatin" in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, including the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic responses in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined.

Indexed as

bioactive glassbonecompositegelatintissue engineering

Identifiers

PMID36662070
PMCPMC9861949
OpenAlexW4313388778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.