Evidence map›Paper›PMID 36662055›Full record

ReviewJournal of functional biomaterials2022

Engineering Dental Tissues Using Biomaterials with Piezoelectric Effect: Current Progress and Future Perspectives.

Sumanta Ghosh, Wei Qiao, Zhengbao Yang, Santiago Orrego, Prasanna Neelakantan

Open access · goldAbstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Injectable Piezoelectric Hydrogel for Vital Pulp Therapy.Journal of functional biomaterials · 2025
    Article
  9. Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Review
  11. Review
  12. Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Review
  14. Review
  15. Review
  16. Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  17. Bioelectricity in dental medicine: a narrative review.Biomedical engineering online · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sumanta GhoshFaculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-0022-0279
Wei QiaoFaculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Zhengbao YangDepartment of Mechanical Engineering & Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong, China.
Santiago OrregoOral Health Sciences Department, Kornberg School of Dentistry, Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0003-3683-6750
Prasanna NeelakantanFaculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-3025-7598
University of Hong Kong · HKCity University of Hong Kong · HKTemple University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental caries and traumatic injuries to teeth may cause irreversible inflammation and eventual death of the dental pulp. Nevertheless, predictably, repair and regeneration of the dentin-pulp complex remain a formidable challenge. In recent years, smart multifunctional materials with antimicrobial, anti-inflammatory, and pro-regenerative properties have emerged as promising approaches to meet this critical clinical need. As a unique class of smart materials, piezoelectric materials have an unprecedented advantage over other stimuli-responsive materials due to their inherent capability to generate electric charges, which have been shown to facilitate both antimicrobial action and tissue regeneration. Nonetheless, studies on piezoelectric biomaterials in the repair and regeneration of the dentin-pulp complex remain limited. In this review, we summarize the biomedical applications of piezoelectric biomaterials in dental applications and elucidate the underlying molecular mechanisms contributing to the biological effect of piezoelectricity. Moreover, we highlight how this state-of-the-art can be further exploited in the future for dental tissue engineering.

Indexed as

bio-piezoelectricitydentin-pulp complexmechanosensitive ion channelpiezo-1 receptorpiezoelectric biomaterialsregenerative endodonticstissue engineering

Identifiers

PMID36662055
PMCPMC9867283
OpenAlexW4313596357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.