Evidence map›Paper›PMID 36661808›Full record

ArticleGels (Basel, Switzerland)2023

Calcium-Polyphosphate Submicroparticles (CaPP) Improvement Effect of the Experimental Bleaching Gels' Chemical and Cellular-Viability Properties.

Mariángela Ivette Guanipa Ortiz, Juliana Jarussi Dos Santos, Jonny Burga Sánchez, Ubirajara Pereira Rodrigues-Filho, Flávio Henrique Baggio Aguiar, Klaus Rischka, Débora Alves Nunes Leite Lima

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. High-Concentration Hydrogen Peroxide Gels Containing Calcium Polyphosphate Associated With Violet Led Light: Bleaching Efficacy and Effects on Enamel Properties.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariángela Ivette Guanipa OrtizDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, Brazil.ORCID 0000-0003-1191-1339
Juliana Jarussi Dos SantosGroup of Chemistry of Hybrid and Inorganic Materials (GQMATHI), São Carlos Institute of Chemistry, University of São Paulo (USP), São Carlos 13563-120, Brazil.
Jonny Burga SánchezDepartment of Physiological Science, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, Brazil.
Ubirajara Pereira Rodrigues-FilhoGroup of Chemistry of Hybrid and Inorganic Materials (GQMATHI), São Carlos Institute of Chemistry, University of São Paulo (USP), São Carlos 13563-120, Brazil.
Flávio Henrique Baggio AguiarDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, Brazil.
Klaus RischkaDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, Brazil.ORCID 0000-0003-3427-4037
Débora Alves Nunes Leite LimaDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001São Paulo Research Foundation 2019/202721
6 · The paper itself

Abstract

The aim of this research was to develop and characterize the chemical and cellular-viability properties of an experimental high-concentration bleaching gel (35 wt%-H2O2) containing calcium-polyphosphate particles (CaPP) at two concentrations (0.5 wt% and 1.5 wt%). The CaPP submicroparticles were synthesized by coprecipitation, keeping a Ca:P ratio of 2:1. The CaPP morphology, size, and chemical and crystal profiles were characterized through scanning and transmission electron microscopy, energy-dispersive X-ray analysis, and X-ray diffraction, respectively. The assessed bleaching gels were experimental (without CaPP); 0.5% CaPP; 1.5% CaPP; and commercial. The gels’ pH values and H2O2 concentrations (iodometric titration) were determined. The odontoblast-like cell viability after a gel’s exposure was assessed by the MTT assay. The pH and H2O2 concentration were compared through a repeated-measures analysis of variance (ANOVA) and a Tukey’s test and the cell viability through a one-way ANOVA and a Tukey’s test using a GraphPad Prism (α < 0.05). The CaPP particles were spherical (with Ca and P, 135.7 ± 80.95 nm size) and amorphous. The H2O2 concentration decreased in all groups after mixing (p < 0.001). The 0.5% CaPP resulted in more-stable pH levels and higher viability levels than the experimental one (p < 0.05). The successful incorporation of CaPP had a positive impact on the bleaching gel’s chemical and cellular-viability properties when compared to the experimental gel without these particles.

Indexed as

bleachingcell survivalhydrogen peroxidepHpolyphosphatessubmicroparticles

Identifiers

PMID36661808
PMCPMC9857579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.