ArticleGels (Basel, Switzerland)2023
pH Sensitive Drug Delivery Behavior of Palmyra Palm Kernel Hydrogel of Chemotherapeutic Agent.
Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Spray-dried pH-sensitive chitosan microparticles loaded with Mycobacterium bovis BCG intended for supporting treatment of Helicobacter pylori infection.Scientific reports · 2024Article
- pH-Sensitive Hydrogel Bilayers: Investigation on Transient Swelling-Induced Bending through Analytical and FEM Approaches.Gels (Basel, Switzerland) · 2023Article
- Mesoporous Materials Make Hydrogels More Powerful in Biomedicine.Gels (Basel, Switzerland) · 2023Review
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Authors and funding
6 authors.
Funding
Abstract
This study examined the gel behavior of naturally-occurring palmyra palm kernel (PPK). Due to the presence of polysaccharide in PPK hydrogels, they exhibit excellent swelling behavior in response to pH. Chemotherapeutic drug 5-fluorouracil (5-FU) was encapsulated in these gels using an equilibrium swelling technique. It was found that 5-FU had an encapsulation efficiency of up to 62%. To demonstrate the drug stability in the gels, the PPK hydrogels were characterized using fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The results showed that the PPK hydrogel matrix contained molecularly dispersed 5-FU drug. The PPK hydrogel exhibited a denser structure and a rough surface, according to images obtained by scanning electron microscopy. In vitro release tests were carried out at pH 1.2 (gastric fluid) and 7.4 (intestinal fluid). The efficacy of the encapsulation and the release patterns were influenced by the network topology of the PPK hydrogel. The release patterns showed that 5-FU was released gradually over a time internal of more than 12 h. The findings suggest that naturally-occurring PPK hydrogels loaded with chemotherapeutic drugs could be employed to treat colon cancer.
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Registered trials
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