Evidence map›Paper›PMID 36661493›Full record

ArticleCurrent issues in molecular biology2022

Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach.

Lakshmi Ranganatha Venkataravanappa, Mahima Jyothi, Hussien Ahmed Khamees, Ekaterina Silina, Victor Stupin, Raghu Ram Achar, Mohammed Al-Ghorbani, Shaukath Ara Khanum

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lakshmi Ranganatha VenkataravanappaDepartment of Chemistry, The National Institute of Engineering, Mysuru 570008, Karnataka, India.
Mahima JyothiDepartment of Chemistry, Yuvaraja's College (Autonomous), University of Mysore, Mysuru 570005, Karnataka, India.
Hussien Ahmed KhameesDepartment of Medical Science, Community College-Abs, Hajjah ABS-00967, Yemen.ORCID 0000-0002-7500-2823
Ekaterina SilinaDepartment of Surgery, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0002-0246-5149
Victor StupinDepartment of Surgery, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Raghu Ram AcharDivision of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, India.ORCID 0000-0001-8196-3703
Mohammed Al-GhorbaniDepartment of Chemistry, College of Science and Arts, Ulla, Taibah University, Medina 41477, Saudi Arabia.ORCID 0000-0002-9079-5788
Shaukath Ara KhanumDepartment of Chemistry, Yuvaraja's College (Autonomous), University of Mysore, Mysuru 570005, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a−n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a−n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds 9a, 9e, and 9g as a lead molecule demonstrated a good inhibition against tested strains. Further, molecular docking studies have been performed for the potent compounds to check the three-dimensional geometrical view of the ligand binding to the targeted proteins.

Indexed as

2-Azetidinoneantimicrobialbenzophenonein silicoin vitromolecular docking simulations

Identifiers

PMID36661493
PMCPMC9857151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.