ArticleBMJ global health2022
Aetiology and incidence of diarrhoea requiring hospitalisation in children under 5 years of age in 28 low-income and middle-income countries: findings from the Global Pediatric Diarrhea Surveillance network.
Article in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 5 of them syntheses that pooled it.
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102 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Adherence to oral zinc supplementation in the management of acute diarrhoeal disease among under-5 children: A systematic review and meta-analysis.Epidemiology and infection · 2025Pooled it
- Burden of Shigella among children with diarrhea in the Americas: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- A systematic review and meta-analysis of the global prevalence of human enteric adenovirus infections.Journal of infection and public health · 2025Pooled it
- Estimated global and regional causes of deaths from diarrhoea in children younger than 5 years during 2000-21: a systematic review and Bayesian multinomial analysis.The Lancet. Global health · 2024Pooled it
- Epidemiology of Rotavirus in Humans, Animals, and the Environment in Africa: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2024Pooled it
- Oral rehydration salts utilization in pediatric diarrhea management among Chinese pediatricians: a national survey.Translational pediatrics · 2026Article
- Article
- Molecular detection of pathogens associated with childhood gastroenteritis in Burkina Faso using the FilmArrayBMC infectious diseases · 2026Article
- The consequences ofEClinicalMedicine · 2026Article
- Incidence of acute diarrhoea among children (0-59 months old) in Thailand after introduction of rotavirus vaccine: a retrospective national database analysis (2014-2024).The Lancet regional health. Southeast Asia · 2026Article
- Protocols for genomic epidemiology and source attribution of enteric bacteria causing diarrhoeal disease across Africa.BMJ open · 2026Article
- Epidemiological and genetic characteristics of a sapovirus GI.6 acute gastroenteritis outbreak in Jiangxi, China.Scientific reports · 2026Article
- Antimicrobial resistance and toxin profiles of enterotoxigenic Escherichia coli in children under five years old with diarrhoea in Ouagadougou, Burkina Faso: a sentinel surveillance study.BMC infectious diseases · 2026Article
- Knowledge, attitudes, and practices of women related to human and animal feces management in Ethiopia: Evidence for strengthening water, sanitation, and hygiene (WaSH) initiatives.One health (Amsterdam, Netherlands) · 2026Article
- Burden of diarrhoeal diseases among hospitalised patients in Thailand: a retrospective national database analysis (2014-2022).The Lancet regional health. Southeast Asia · 2026Article
- The incidence and antimicrobial resistance of Shigella-attributable diarrhoea in young children in low-income and middle-income countries from the multicountry Enterics for Global Health (EFGH) Shigella Surveillance Study: a prospective, facility-based hybrid surveillance study.The Lancet. Global health · 2026Article
- Burden of diarrheal diseases among children under five in East Africa, 2000-2023: insights from the global burden of disease 2023 study.BMC infectious diseases · 2026Article
- Mapping paediatric acute gastroenteritis in Talavera, Nueva Ecija, Philippines: a cross-sectional study on prevalence and community risk factors.BMJ paediatrics open · 2026Article
- Oral rotavirus vaccine effectiveness among malnourished children in 19 countries: Findings from the MNSSTER-V project.Journal of pediatric gastroenterology and nutrition · 2026Article
- Rotavirus Outbreak Traced in Clinical, Environmental, and Food Matrices: Whole Genomic Characterization of an Equine-like G3P[8] Genotype.Food and environmental virology · 2026Article
42 more citing papers are in PubMed but not listed here.
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Abstract
introductionDiarrhoea remains a leading cause of child morbidity and mortality. Systematically collected and analysed data on the aetiology of hospitalised diarrhoea in low-income and middle-income countries are needed to prioritise interventions.
methodsWe established the Global Pediatric Diarrhea Surveillance network, in which children under 5 years hospitalised with diarrhoea were enrolled at 33 sentinel surveillance hospitals in 28 low-income and middle-income countries. Randomly selected stool specimens were tested by quantitative PCR for 16 causes of diarrhoea. We estimated pathogen-specific attributable burdens of diarrhoeal hospitalisations and deaths. We incorporated country-level incidence to estimate the number of pathogen-specific deaths on a global scale.
resultsDuring 2017-2018, 29 502 diarrhoea hospitalisations were enrolled, of which 5465 were randomly selected and tested. Rotavirus was the leading cause of diarrhoea requiring hospitalisation (attributable fraction (AF) 33.3%; 95% CI 27.7 to 40.3), followed by
conclusionsDespite the substantial impact of rotavirus vaccine introduction, rotavirus remained the leading cause of paediatric diarrhoea hospitalisations. Improving the efficacy and coverage of rotavirus vaccination and prioritising interventions against
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