Evidence map›Paper›PMID 36660548›Full record

ArticleFrontiers in immunology2022

The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during

Erika S Guimarães, Marco Túlio R Gomes, Rodrigo C O Sanches, Kely Catarine Matteucci, Fábio V Marinho, Sergio C Oliveira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Journal of medical microbiology · 2026
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  14. Effect of SiHuangQingXinWan onFrontiers in pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Erika S GuimarãesDepartamento de Genética, Ecologia e Evolução, Programa de Pós-Graduação em Genética, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Marco Túlio R GomesDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Rodrigo C O SanchesDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Kely Catarine MatteucciDepartamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Fábio V MarinhoDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Sergio C OliveiraDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade de Ribeirão Preto · BRUniversidade de São Paulo · BR

Funding

Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunityR01AI116453 · NIAID · FOUNDATION FOR RESEARCH DEVELOPMENT · PI BARBER, GLEN N, OLIVEIRA, SERGIO C · 2016 to 2025
$1.4M
NIAID NIH HHS R01 AI116453
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress plays a major role in several inflammatory disorders. ER stress induces the unfolded protein response (UPR), a conserved response broadly associated with innate immunity and cell metabolic function in various scenarios.

Indexed as

Brucella abortusBrucellosis, BovineMacrophagesAnimalsCattleEndoplasmic Reticulum StressEndoribonucleasesProtein Serine-Threonine KinasesEndoribonucleasesProtein Serine-Threonine Kinasesbrucella abortusendoplasmic reticulum stressHIF-1αimmunometabolismIRE1αUPR

Identifiers

PMID36660548
PMCPMC9842658
OpenAlexW4313519275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.