Evidence map›Paper›PMID 36660541›Full record

ArticleBMJ neurology open2023

Differential age-associated brain atrophy and white matter changes among homeless and precariously housed individuals compared with the general population.

Jacob L Stubbs, Andrea A Jones, Daniel Wolfman, Ryan C Y Chan, Fidel Vila-Rodriguez, Alexandra T Vertinsky, Manraj K Heran, Wayne Su, Donna J Lang, Thalia S Field and 9 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ neurology open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Observational
  3. An Understated Comorbidity: The Impact of Homelessness on Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Jacob L StubbsDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Andrea A JonesDivision of Neurology, University of British Columbia, Vancouver, BC, Canada.
Daniel WolfmanDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Ryan C Y ChanDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Fidel Vila-RodriguezDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Alexandra T VertinskyDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Manraj K HeranDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Wayne SuDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Donna J LangBritish Columbia Mental Health and Substance Use Services Research Institute, Vancouver, BC, Canada.
Thalia S FieldDivision of Neurology, University of British Columbia, Vancouver, BC, Canada.
Kristina M GicasDepartment of Psychology, York University, Toronto, ON, Canada.
Melissa L WoodwardDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Allen E ThorntonBritish Columbia Mental Health and Substance Use Services Research Institute, Vancouver, BC, Canada.
Alasdair M BarrDepartment of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Olga LeonovaDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
William MacEwanDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
Alexander RauscherDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
William G HonerDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
William J PanenkaDepartment of Psychaitry, University of British Columbia, Vancouver, BC, Canada.
University of British Columbia · CABC Mental Health & Substance Use Services · CAYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Homeless or precariously housed individuals live with poor health and experience premature mortality compared with the general population, yet little is known about age-related brain changes among these individuals. We evaluated whether MRI measures of brain structure are differentially associated with age and selected risk factors among individuals who are homeless or precariously housed compared with a general population sample. Methods: We compared T1-weighted and diffusion tensor imaging measures of brain macrostructure and white matter microstructure in a well-characterised sample of 312 precariously housed participants with a publicly available dataset of 382 participants recruited from the general population. We used piecewise and multiple linear regression to examine differential associations between MRI measures and between the samples, and to explore associations with risk factors in the precariously housed sample. Results: Compared with the general population sample, older age in the precariously housed sample was associated with more whole-brain atrophy (β=-0.20, p=0.0029), lower whole-brain fractional anisotropy (β=-0.32, p<0.0001) and higher whole-brain mean diffusivity (β=0.69, p<0.0001). Several MRI measures had non-linear associations with age, with further adverse changes after age 35-40 in the precariously housed sample. History of traumatic brain injury, stimulant dependence and heroin dependence was associated with more atrophy or alterations in white matter diffusivity in the precariously housed sample. Conclusions: Older age is associated with adverse MRI measures of brain structure among homeless and precariously housed individuals compared with the general population. Education, improvements in care provision and policy may help to reduce the health disparities experienced by these individuals.

Indexed as

ACQUIRED BRAIN INJURYALCOHOL-RELATED PROBLEMSCONCUSSIONHEAD INJURY

Identifiers

PMID36660541
PMCPMC9843194
OpenAlexW4315881065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.