Evidence map›Paper›PMID 36660472›Full record

ArticleGastroenterology research2022

Hospitalization Outcomes of Acute Pancreatitis in Hematopoietic Stem Cell Transplant Recipients.

Hunza Chaudhry, Armaan Dhaliwal, Kanwal Bains, Aalam Sohal, Piyush Singla, Raghav Sharma, Dino Dukovic, Isha Kohli, Gagan Gupta, Devang Prajapati

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Hunza ChaudhryDepartment of Internal Medicine, University of California, San Francisco, Fresno, CA, USA.
Armaan DhaliwalDepartment of Internal Medicine, University of Arizona, South Campus, Tucson, AZ, USA.
Kanwal BainsDepartment of Internal Medicine, University of Arizona, South Campus, Tucson, AZ, USA.
Aalam SohalLiver Institute Northwest, Seattle, WA, USA.
Piyush SinglaDayanand Medical College and Hospital, India.
Raghav SharmaPunjab Institute of Medical Sciences, India.
Dino DukovicRoss University School of Medicine, Barbados.
Isha KohliGraduate School of Public Health, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Gagan GuptaDayanand Medical College and Hospital, India.
Devang PrajapatiDepartment of Gastroenterology and Hepatology, University of California, San Francisco, Fresno, CA, USA.
Dayanand Medical College & Hospital · INUniversity of Arizona · USUniversity of California, San Francisco · USIcahn School of Medicine at Mount Sinai · USLiver Institute Northwest · USPunjab Institute of Medical Sciences · INRoss University School of Medicine · BB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute pancreatitis (AP) carries a significant morbidity and mortality worldwide. AP is a potential complication of hematopoietic stem cell transplantation (HSCT) although its incidence remains unclear. HSCT recipients are at increased risk of AP due to various factors but the effect of AP on mortality and resource utilization in the adult population has not been studied. We investigated the impact of AP on hospitalization outcomes among patients following HSCT. Methods: We queried the National Inpatient Sample (NIS) database using the International Classification of Diseases (ICD)-10 codes. All adult patients with a diagnosis or procedure code of HSCT were included in the study. Patients were divided into those with a diagnosis of AP and those without. Sensitivity analysis was performed for patients with a length of stay greater than 28 days. The relationship between AP and mortality, length of stay, total hospitalization cost, and charges was assessed using univariate analysis followed by multivariate analysis. Results: Of the 140,130 adult patients with HSCT, 855 (0.61%) patients developed AP. There was 1.74 times higher risk of mortality in patients with AP as compared to controls (adjusted odds ratio (aOR): 1.74, P = 0.0055). There was no statistically significant difference in the length of stay, hospitalization charge, or cost before sensitivity analysis. After sensitivity analysis, 13,240 patients were included, from which 125 (0.94%) had AP. There was 3.85 times higher risk of mortality in patients who developed AP as compared to controls (aOR: 3.85, P = 0.003). There was a statistically significant increase noted in the length of stay (adj coeff: 20.3 days, P = 0.002), hospital charges (+$346,616, P = 0.017), and cost (+$121,932.4, P = 0.001) in patients with AP as compared to those who did not develop AP. Conclusion: Recipients of HSCT who develop AP have shown to have higher mortality on sensitivity analysis. This study highlights that AP in HSCT patients is associated with worse outcomes and higher resource utilization. Physicians should be aware of this association as the presence of pancreatitis portends a poor prognosis.

Indexed as

Acute pancreatitisHematopoietic stem cell transplantationHospitalization outcomes

Identifiers

PMID36660472
PMCPMC9822663
OpenAlexW4311978450

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.