Evidence map›Paper›PMID 36660376›Full record

ArticleJournal of inflammation research2023

CHINAT-CD4 Score Predicts Transplant-Free Survival in Patients with Acute-on-Chronic Liver Failure.

Chenlu Huang, Weixia Li, Chong Chen, Wei Xu, Ling Fei, Shuai Tao, Qiankun Hu, Xudong Xie, Xiongyue Cao, Xiao-Yu Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Chenlu Huang *Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.ORCID 0000-0003-1752-1614
Weixia Li *Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Chong Chen *Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Wei XuDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Ling FeiDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Shuai TaoResearch Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Qiankun HuDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Xudong XieDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Xiongyue CaoDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Xiao-Yu ZhangDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.ORCID 0000-0002-2041-9955
Liang ChenDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Qiang LiDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.ORCID 0000-0003-3831-9001
Yuxian HuangDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Shanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The early prognosis evaluation of acute-on-chronic liver failure (ACLF) is important to decrease its mortality. We aimed to develop a new score to accurately predict the outcome of patients with ACLF. Methods: A derivation set of 408 patients with hepatitis B virus-related ACLF (HBV-ACLF) based on the Asian Pacific Association for the Study of the Liver criteria is used to develop a prognostic score that was validated in 209 patients with HBV-ACLF and 195 patients with non-HBV-ACLF. Results: Seven factors were significantly related to the 28-day mortality and constituted a new score (CHINAT-CD4 = 0.320 × ln (creatinine) + 0.668 × hepatic encephalopathy score + 0.745 × ln (international normalized ratio) + 0.476 × ln (neutrophil) + 0.251 × ln (aspartate aminotransferase) + 0.411 × ln (total bilirubin) - 0.605 × ln (CD4+ T cells count)). The C-indices of the new score for the 28-/90-day mortality (0.810/0.806) outperformed those of the other seven scores ( Conclusion: The novel score based on CD4

Indexed as

chronic liver diseaseinflammatory markersliver failureprognostic scorerisk stratification

Identifiers

PMID36660376
PMCPMC9844105
OpenAlexW4317567098

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.