Evidence map›Paper›PMID 36660314›Full record

ArticlePolymer chemistry2018

Fully synthetic macromolecular prodrug chemotherapeutics with EGFR targeting and controlled camptothecin release kinetics.

Hanna Freeman, Selvi Srinivasan, Debobrato Das, Patrick S Stayton, Anthony J Convertine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. A macrophage-targeted platform for extending drug dosing with polymer prodrugs for pulmonary infection prophylaxis.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hanna FreemanMolecular Engineering and Sciences Institute, department of BioEngineering, Box 355061, Seattle WA, 98195, USA.
Selvi SrinivasanMolecular Engineering and Sciences Institute, department of BioEngineering, Box 355061, Seattle WA, 98195, USA.
Debobrato DasMolecular Engineering and Sciences Institute, department of BioEngineering, Box 355061, Seattle WA, 98195, USA.
Patrick S StaytonMolecular Engineering and Sciences Institute, department of BioEngineering, Box 355061, Seattle WA, 98195, USA.
Anthony J ConvertineDepartment of Material Science and Engineering, Missouri University of Science and Technology, Rolla MO, 65401, USA.
Health and Environmental Sciences Institute · USMissouri University of Science and Technology · US

Funding

Engineered Antimicrobial Platform to Target Pulmonary Intracellular InfectionsR01AI134729 · NIAID · UNIVERSITY OF WASHINGTON · PI Shawn J. Skerrett, Patrick S. Stayton · 2018 to 2026
$4.9M
Biofunctional Polymers for Intracellular Drug DeliveryR01EB002991 · NIBIB · UNIVERSITY OF WASHINGTON · PI STAYTON, PATRICK S. · 2003 to 2011
$3.9M
Intracellular delivery of proapoptotic peptide drugs for the treatment of cancerR21EB014572 · NIBIB · UNIVERSITY OF WASHINGTON · PI STAYTON, PATRICK S. · 2012 to 2013
$450k
Multifunctional polymeric carriers for the intracellular delivery of protein cancer therapeuticsF30CA183263 · NCI · UNIVERSITY OF WASHINGTON · PI KERN, HANNA BETH · 2015 to 2017
$113k
NCI NIH HHS F30 CA183263NIAID NIH HHS R01 AI134729NIBIB NIH HHS R01 EB002991NIBIB NIH HHS R21 EB014572
6 · The paper itself

Abstract

Herein, we developed a fully polymerizable, peptide-targeted, camptothecin polymeric prodrug system. Two prodrug monomers were synthesized

Identifiers

PMID36660314
PMCPMC9847574
OpenAlexW2893225208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.