Evidence map›Paper›PMID 36660061›Full record

ArticleCardiology research2022

One Acute Exposure to E-Cigarette Smoke Using Various Heating Elements and Power Levels Induces Pulmonary Inflammation.

Jianru Shi, Wangde Dai, Jesus Chavez, Juan Carreno, Lifu Zhao, Michael T Kleinman, Rebecca J Arechavala, Irene Hasen, Amanda Ting, Bishop Bliss and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jianru ShiCardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Wangde DaiCardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Jesus ChavezCardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Juan CarrenoCardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Lifu ZhaoCardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Michael T KleinmanDepartment of Environmental and Occupational Health, University of California, Irvine, CA 92717, USA.
Rebecca J ArechavalaDepartment of Environmental and Occupational Health, University of California, Irvine, CA 92717, USA.
Irene HasenDepartment of Environmental and Occupational Health, University of California, Irvine, CA 92717, USA.
Amanda TingDepartment of Environmental and Occupational Health, University of California, Irvine, CA 92717, USA.
Bishop BlissDepartment of Environmental and Occupational Health, University of California, Irvine, CA 92717, USA.
Jessica E Monterrosa MenaDepartment of Environmental and Occupational Health, University of California, Irvine, CA 92717, USA.
Robert A KlonerCardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Huntington Medical Research Institutes · USIrvine University · USUniversity of California, Irvine · USUniversity of Southern California · US

Funding

The effect of electronic cigarettes on young versus old normal hearts and pathologic heartsR01HL144258 · NHLBI · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI KLONER, ROBERT A · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL144258
6 · The paper itself

Abstract

Background: Electronic cigarettes (eC) may not be entirely benign. There is a lack of data on the effect of a single acute exposure of eC vapor using various heating sources and power settings upon lung injury. The purpose of this study was to determine if an acute exposure with eC vapor heated with different heating elements and power levels induced inflammatory changes in the lungs and heart. Methods: Rats were exposed to pure air or received a single, 4-h exposure to eC vapor. The devices used either a stainless steel (SS) or nichrome (NC) heating element randomized to a low or high atomization power (45 versus 70 W). Rats were euthanized within 48 h of exposure. Results: The eC groups showed accumulation of inflammatory cells in bronchial lumen, near the pleura, and within the alveolar spaces. The numbers of inflammatory cells per field in the lung parenchyma were significantly greater in the rats exposed to eC groups vs. the air group. There were significantly higher inflammatory gene expression changes in the lungs of animals assigned to 70 W power. We observed that eC vapor generated using burnt coils were toxic and could cause acute respiratory distress and myocarditis. Conclusion: In conclusion, one 4-h exposure to eC vapor, in the absence of vitamin E oil or nicotine, significantly increased lung inflammation. Effects were seen after exposures to vapor generated using SS and NC heating elements at either high or low power. Vapor from devices with burnt coils can negatively affect the heart and lung.

Indexed as

Burnt coilE-cigaretteLung inflammationVaping

Identifiers

PMID36660061
PMCPMC9822672
OpenAlexW4311616657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.